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Inarigivir {[allProObj[0].p_purity_real_show]}

货号：A167476 同义名： ORI-9020;SB-9000

Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus.

Inarigivir 化学结构 CAS号：475650-36-3
Inarigivir 化学结构
CAS号：475650-36-3
Inarigivir 3D分子结构
CAS号：475650-36-3
Inarigivir 化学结构 CAS号：475650-36-3
Inarigivir 3D分子结构 CAS号：475650-36-3
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Inarigivir 纯度/质量文件 产品仅供科研

货号：A167476 标准纯度： {[allProObj[0].p_purity_real_show]}
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Inarigivir 生物活性

描述 Chronic hepatitis B virus infection (HBV) continues to pose a serious global health threat in many areas of the world, particularly in sub-Saharan Africa, the Western Pacific Region and areas of Eastern Europe[1]. Inarigivir, a novel dinucleotide, evaluated in transgenic mice expressing HBV, significantly reduced liver HBV DNA (P ≤ 0.001)[2]. The mode of antiviral action of Inarigivir appears to be direct interference of HBV replication at the level of HBV reverse transcriptase and/or DNA polymerase at an early step, either at, or prior to, the production of the first strand of HBV DNA. I.p. injection of Inarigivir at 100 mg/kg/day significantly reduced viral DNA in the liver (P ≤ 0.001) and showed anti-HBV activity similar to that of ADV. The minimal effective dosage of Inarigivir was identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[2].

Inarigivir 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03493698 Drug Interaction Potentiation Phase 1 Completed - Netherlands ... 展开 >> University Medical Center Groningen Groningen, Netherlands 收起 <<
NCT03434353 Chronic Hepatitis b Phase 2 Recruiting June 2020 Hong Kong ... 展开 >> Alice Ho Miu Ling Nethersole Hospital Recruiting Hong Kong, Hong Kong Prince of Wales Hospital-HK Recruiting Hong Kong, Hong Kong Korea, Republic of Korea University Ansan Hospital Recruiting Ansan, Korea, Republic of, 425-707 Keimyung University Dongsan Medical Center Recruiting Daegu, Korea, Republic of, 41931 Kyungpook National University Hospital Recruiting Daegu, Korea, Republic of, 41944 Inje University Ilsan Paik Hospital Recruiting Ilsan, Korea, Republic of, 10380 Severance Hospital, Yonsei University Health System Recruiting Seoul, Korea, Republic of, 03722 Asan Medical Center Recruiting Seoul, Korea, Republic of, 05505 Gangnam Severance Hospital, Yonsei University Health System Recruiting Seoul, Korea, Republic of, 06273 Catholic University of Korea, Seoul Saint Mary's Hospital Recruiting Seoul, Korea, Republic of, 06591 SMG-SNU Boramae Medical Center Recruiting Seoul, Korea, Republic of, 07061 Korea University Guro Hospital Recruiting Seoul, Korea, Republic of, 08308 收起 <<

Inarigivir 参考文献

[1]Ginzberg D, Wong RJ, Gish R. Global HBV burden: guesstimates and facts. Hepatol Int. 2018 Jul;12(4):315-329. doi: 10.1007/s12072-018-9884-8. Epub 2018 Jul 27. PMID: 30054801.

[2]Iyer RP, Roland A, Jin Y, Mounir S, Korba B, Julander JG, Morrey JD. Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model. Antimicrob Agents Chemother. 2004 Jun;48(6):2318-20. doi: 10.1128/AAC.48.6.2318-2320.2004. PMID: 15155244; PMCID: PMC415565.

Inarigivir 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.70mL

0.34mL

0.17mL

8.51mL

1.70mL

0.85mL

17.02mL

3.40mL

1.70mL

Inarigivir 技术信息

CAS号475650-36-3
分子式C20H26N7O10PS
分子量 587.5
别名 ORI-9020;SB-9000
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C
溶解度

DMSO: 190 mg/mL(323.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Inarigivir | 475650-36-3 | ORI-9020 | SB-9000 | ORI9020 | ORI 9020 | SB9000 | SB 9000 | SB-9000 | HBV Inhibitor | Anti-infection | HBV | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Inarigivir 纯度/质量文件 | Inarigivir 生物活性 | Inarigivir 临床数据 | Inarigivir 参考文献 | Inarigivir 实验方案 | Inarigivir 技术信息

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