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双环醇 /Bicyclol {[allProObj[0].p_purity_real_show]}

货号:A598610 同义名: Bicyclol游离态 / SY801

Bicyclol (SY 801) 是一种具有抗 HBV 和抗 HCV 性质的口服活性化合物。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Bicyclol 化学结构 CAS号:118159-48-1
Bicyclol 化学结构
CAS号:118159-48-1
Bicyclol 3D分子结构
CAS号:118159-48-1
Bicyclol 化学结构 CAS号:118159-48-1
Bicyclol 3D分子结构 CAS号:118159-48-1
规格 价格 会员价 库存 数量
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Bicyclol 纯度/质量文件 产品仅供科研

货号:A598610 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Autophagy 其他靶点 纯度
SBI-0206965 +++

ULK2, IC50: 711 nM

ULK1, IC50: 108 nM

97%
Hydroxychloroquine sulfate 99%
Valproic acid sodium HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

99%+
MRT68921 hydrochloride ++++

ULK2, IC50: 1.1 nM

ULK1, IC50: 2.9 nM

99%+
ROC-325 99%+
Autophinib +++

Autophagy, IC50: 40 nM

97%
Lys05 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Bicyclol 生物活性

描述 Bicyclol (SY 801), an anti-hepatitis medication, has demonstrated effectiveness in reducing elevated serum transaminases (ALT, AST) by about 50% in patients with chronic hepatitis B and C. It also exhibits a capacity to inhibit replication of HBV and HCV. No significant adverse reactions have been noted. When used in combination with interferon alpha, lamivudine, and adefovir dipivoxil for treating HBV or HCV, bicyclol may enhance antiviral efficacy and reduce YMDD mutants and side effects. In 2004, the China FDA approved bicyclol for production, and since then, it has been extensively employed to treat chronic HBV and HCV in China[1].

Bicyclol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03680183 - Recruiting December 31, 2021 China, Guangdong ... 展开 >> Affiliated Cancer Hospital & Institute of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510182 Contact: Wenying Shu, PhD    86-20-66673666 ext 2006    790840799@qq.com    Contact: Tiantian Cheng, MD    86-20-66673677    gyzlgcp@163.com 收起 <<
NCT02961413 - Recruiting December 2018 China ... 展开 >> Renji hospital Recruiting Shanghai, China Contact: Yimin Mao 收起 <<
NCT02944552 Drug-Induced Acute Liver Injur... 展开 >>y 收起 << Phase 2 Recruiting August 2019 China, Beijing ... 展开 >> Beijing Chest Hospital, Capital Medical University Recruiting Beijing, Beijing, China, 101149 Contact: Naihui Chu          China, Fujian Fuzhou General Hospital of Nanjing Military Command Recruiting Fuzhou, Fujian, China, 350025 Contact: Dongliang Li          China, Shanghai Renji Hospital ,Shanghai Jiao Tong University School of Medicine Recruiting Shanghai, Shanghai, China, 200127 Contact: Yimin Mao    13003175438    maoym11968@163.com    No.85 hospital of PLA Recruiting Shanghai, Shanghai, China Contact: Chengwei Chen    13901989118    ccw2@163.com 收起 <<

Bicyclol 参考文献

[1]Walsh, S.W., Y. Wang, and A. Killian, AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. J Pharmacol Exp Ther, 1999. 290(1): p. 220-6.

Bicyclol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.56mL

0.51mL

0.26mL

12.81mL

2.56mL

1.28mL

25.62mL

5.12mL

2.56mL

Bicyclol 技术信息

CAS号118159-48-1
分子式C19H18O9
分子量 390.341
别名 Bicyclol游离态 ;SY801
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(269 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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