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Tenofovir alafenamide fumarate
替诺福韦艾拉酚胺富马酸盐 /Tenofovir alafenamide fumarate
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货号：A167277
同义名：
GS-7340 fumarate;TAF fumarate
Tenofovir alafenamide fumarate 是替诺福韦的前药，是一种逆转录酶抑制剂，能够阻止HIV的复制。
Tenofovir alafenamide fumarate 化学结构
Tenofovir alafenamide fumarate 3D分子结构
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Tenofovir alafenamide fumarate 纯度/质量文件 产品仅供科研
货号：A167277
标准纯度：
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Tenofovir alafenamide fumarate 质控信息
Tenofovir alafenamide fumarate 生物活性
描述
GS-7340 Fumarate (tenofovir alafenamide: TAF) is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection that has efficacy similar to that of TDF (tenofovir disoproxil fumarate) and improved safety compared with TDF[3] [4] [5]
Tenofovir alafenamide fumarate 参考文献
[1] Ruane PJ, DeJesus E, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55.
[2] Koziol E, Skalicka-Wozniak K. Imperatorin-pharmacological meaning and analytical clues: profound investigation. Phytochem Rev. 2016;15:627-649.
[3] Gibson AK, Shah BM, Nambiar PH, Schafer JJ. Tenofovir Alafenamide. Ann Pharmacother. 2016 Nov;50(11):942-952
[4] Ruane PJ, DeJesus E, Berger D, Markowitz M, Bredeek UF, Callebaut C, Zhong L, Ramanathan S, Rhee MS, Fordyce MW, Yale K. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55
[5] De Clercq E. Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF). Biochem Pharmacol. 2016 Nov 1;119:1-7
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Tenofovir alafenamide fumarate 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.69mL
0.34mL
0.17mL
8.44mL
1.69mL
0.84mL
16.88mL
3.38mL
1.69mL
Tenofovir alafenamide fumarate 技术信息
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