Isoscopoletin
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货号：A554035
同义名：
6-Hydroxy-7-methoxycoumarin;Esculetin 7-methyl ether
Isoscopoletin 是一种从艾叶中提取的活性成分，具有显著的细胞增殖抑制作用。对 CCRF-CEM 白血病细胞和其耐药亚系 CEM/ADR5000 的 IC50 分别为 4.0 μM 和 1.6 μM。它还具有抑制 HBV 复制的活性。
Isoscopoletin 化学结构
Isoscopoletin 3D分子结构
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Isoscopoletin 纯度/质量文件 产品仅供科研
货号：A554035
标准纯度：
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Isoscopoletin 质控信息
Isoscopoletin 生物活性
描述
Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[3] [4] [5]
Isoscopoletin 参考文献
[1] Cheng F, Deng Z, et al. Machilusmarin, a new neuroprotective isocoumarin dimer from the stems of Machilus ichangensis Rehd. et Wils. Nat Prod Res. 2013;27(17):1542-7.
[2] Adams M, Efferth T, Bauer R. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4.
[3] Adams M, Efferth T, Bauer R. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4
[4] Li H, Zhou C, Pan Y, Gao X, Wu X, Bai H, Zhou L, Chen Z, Zhang S, Shi S, Luo J, Xu J, Chen L, Zheng X, Zhao Y. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33
[5] Zhao DD, Zhao QS, Liu L, Chen ZQ, Zeng WM, Lei H, Zhang YL. Compounds from Dryopteris fragrans (L.) Schott with cytotoxic activity. Molecules. 2014 Mar 18;19(3):3345-55
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Isoscopoletin 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
5.20mL
1.04mL
0.52mL
26.02mL
5.20mL
2.60mL
52.04mL
10.41mL
5.20mL
Isoscopoletin 技术信息
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