Y-27632
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货号：A112358
Y-27632 是一种口服有效的、ATP 竞争性的 ROCK -I 和 ROCK -II 抑制剂，Ki 值分别为 220 nM 和 300 nM。
Y-27632 化学结构
Y-27632 3D分子结构
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Y-27632 纯度/质量文件 产品仅供科研
货号：A112358
标准纯度：
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Y-27632 质控信息
Y-27632 生物活性
描述
Y-27632 is a specific inhibitor of Rho-associated kinases[1] [2] [3] [4] [5]
作用机制
Y-27632 can inhibit ROCK1 and ROCK2 in an ATP-competition manner.[1]
Y-27632 动物研究
Dose
Mice: 1 mg/kg - 5 mg/kg[8] [7] [9]
Administration
i.p.
Y-27632 参考文献
[1] Ishizaki T, Uehata M, et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83.
[2] Li X, Meng G, et al. The ROCK inhibitor Y-27632 enhances the survival rate of human embryonic stem cells following cryopreservation. Stem Cells Dev. 2008 Dec;17(6):1079-85.
[3] Zhao Y, Zhao T, et al. A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming. Cell. 2015 Dec 17;163(7):1678-91.
[4] Gauthaman K, Fong CY, et al. ROCK inhibitor Y-27632 increases thaw-survival rates and preserves stemness and differentiation potential of human Wharton's jelly stem cells after cryopreservation. Stem Cell Rev. 2010 Dec;6(4):665-76.
[5] Wang T, Kang W, et al. Rho-kinase inhibitor Y-27632 facilitates the proliferation, migration and pluripotency of human periodontal ligament stem cells. J Cell Mol Med. 2017 Nov;21(11):3100-3112.
[6] Osei-Owusu P, Knutsen RH, et al. Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency. Am J Physiol Heart Circ Physiol. 2014;306(5):H654-66.
[7] Mavria G, Vercoulen Y, et al. ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis. Cancer Cell. 2006;9(1):33-44.
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Y-27632 实验方案
计算器
摩尔计算器
总药量计算器
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
4.04mL
0.81mL
0.40mL
20.22mL
4.04mL
2.02mL
40.43mL
8.09mL
4.04mL
Y-27632 技术信息
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