WS3 is an Erb3 binding protein-1 (EBP1) and IκB kinase pathway modulator, it's a non-specific proliferative molecule and promotes β cell proliferation with EC50 of 28 nM.
WS3 is a novel proliferative molecule that promotes pancreatic β cell proliferation in rodent and human primary islets. WS3 can be used for the research of type 1 diabetes. WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC50 value of 0.28 μM[3]. WS3 (1.0 nM-1.0 µM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments[4]. WS1 and WS3 are caused by mutation in the gene encoding the transcription factor Pax3, which regulates MITF (Microphthalmia-associated transcription factor) expression[5].
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