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/ VULM 1457

VULM 1457 {[allProObj[0].p_purity_real_show]}

货号：A950228 Ambeed 开学季，买赠积分，赢豪礼

ACAT inhibitor

VULM 1457 化学结构 CAS号：228544-65-8
VULM 1457 化学结构
CAS号：228544-65-8
VULM 1457 3D分子结构
CAS号：228544-65-8
VULM 1457 化学结构 CAS号：228544-65-8
VULM 1457 3D分子结构 CAS号：228544-65-8
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VULM 1457 纯度/质量文件 产品仅供科研

货号：A950228 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 mTOR ↓ mTORC1 ↓ mTORC2 ↓ 其他靶点 纯度
AZD-8055 ++++

mTOR (full length), IC50: 0.8 nM

mTOR (truncated), IC50: 0.13 nM

 		{[allProObj[0].p_purity_real_show]}
Gedatolisib ++++

mTOR, IC50: 1.6 nM

 		{[allProObj[0].p_purity_real_show]}
GSK1059615 ++

mTOR, IC50: 12 nM

 		{[allProObj[0].p_purity_real_show]}
Vistusertib +++

mTOR, IC50: 2.8 nM

 		{[allProObj[0].p_purity_real_show]}
Torin 1 +++

mTOR, IC50: 4.32 nM

 		+++

mTORC1, IC50: 2 nM

 		++

mTORC2, IC50: 10 nM

 		DNA-PK {[allProObj[0].p_purity_real_show]}
Dactolisib +++

mTOR (p70S6K), IC50: 6 nM

 		{[allProObj[0].p_purity_real_show]}
PI-103 +

mTOR, IC50: 30 nM

 		{[allProObj[0].p_purity_real_show]}
WAY-600 ++

mTOR, IC50: 9 nM

 		{[allProObj[0].p_purity_real_show]}
Voxtalisib +

mTOR, IC50: 157 nM

 		{[allProObj[0].p_purity_real_show]}
PF-04691502 ++

mTOR, Ki: 16 nM

 		{[allProObj[0].p_purity_real_show]}
Onatasertib ++

mTOR, IC50: 16 nM

 		DNA-PK {[allProObj[0].p_purity_real_show]}
Chrysophanol ✔ EGFR {[allProObj[0].p_purity_real_show]}
Samotolisib ✔ DNA-PK {[allProObj[0].p_purity_real_show]}
Torkinib +++

mTOR, IC50: 8 nM

 		DNA-PK,PDGFR {[allProObj[0].p_purity_real_show]}
Everolimus {[allProObj[0].p_purity_real_show]}
WYE-354 +++

mTOR, IC50: 5 nM

 		{[allProObj[0].p_purity_real_show]}
Tacrolimus ✔ {[allProObj[0].p_purity_real_show]}
PP121 ++

mTOR, IC50: 13 nM

 		PDGFR,VEGFR {[allProObj[0].p_purity_real_show]}
Torin 2 ++++

mTOR, IC50: 0.25 nM

 		DNA-PK {[allProObj[0].p_purity_real_show]}
Rapamycin ++++

mTOR, IC50: ~0.1 nM

 		{[allProObj[0].p_purity_real_show]}
GDC-0349 +++

mTOR, Ki: 3.8 nM

 		{[allProObj[0].p_purity_real_show]}
XL388 ++

mTOR, IC50: 9.9 nM

 		+++

mTORC1, IC50: 8 nM

 		+

mTORC2, IC50: 166 nM

 		{[allProObj[0].p_purity_real_show]}
WYE-687 +++

mTOR, IC50: 7 nM

 		{[allProObj[0].p_purity_real_show]}
Apitolisib +

mTOR, Ki app: 17 nM

 		{[allProObj[0].p_purity_real_show]}
WYE-132 ++++

mTOR, IC50: 0.19 nM

 		{[allProObj[0].p_purity_real_show]}
Sapanisertib ++++

mTOR, Ki: 1.4 nM

 		{[allProObj[0].p_purity_real_show]}
BGT226 maleate ✔ {[allProObj[0].p_purity_real_show]}
ETP-46464 ++++

mTOR, IC50: 0.6 nM

 		DNA-PK {[allProObj[0].p_purity_real_show]}
PI3K-IN-1 +

mTOR, IC50: 157 nM

 		{[allProObj[0].p_purity_real_show]}
Zotarolimus +++

FKBP-12, IC50: 2.8 nM

 		{[allProObj[0].p_purity_real_show]}
OSI-027 +++

mTOR, IC50: 4 nM

 		+

mTORC1, IC50: 22 nM

 		+

mTORC2, IC50: 65 nM

 		{[allProObj[0].p_purity_real_show]}
Ridaforolimus ++++

mTOR, IC50: 0.2 nM

 		{[allProObj[0].p_purity_real_show]}
Temsirolimus +

mTOR, IC50: 1.76 μM

 		{[allProObj[0].p_purity_real_show]}
CZ415 ++

mTOR, pIC50: 8.07

 		{[allProObj[0].p_purity_real_show]}
SF2523 +

mTOR, IC50: 280 nM

 		DNA-PK {[allProObj[0].p_purity_real_show]}
KU-0063794 ++

mTORC1, IC50: ~10 nM

 		++

mTORC2, IC50: ~10 nM

 		{[allProObj[0].p_purity_real_show]}
Omipalisib ++++

mTORC1, Ki: 0.18 nM

 		++++

mTORC2, Ki: 0.3 nM

 		{[allProObj[0].p_purity_real_show]}
Palomid 529 ✔ {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

VULM 1457 生物活性

描述 VULM 1457 is a potent inhibitor of cholesterol acyltransferase (acyl-CoA). VULM1457 significantly reduces adrenomedullin (AM) production and secretion and downregulates AM receptors on human hepatocytes. VULM 1457 has significant hypolipidemic activity and can improve the overall efficacy of myocardial ischemia-reperfusion injury. VULM 1457 has the potential to study diabetes and hypercholesterolemia [1][2].VULM 1457 significantly down-regulates specific AM receptors on HepG2 cells at concentrations ranging from 0.03 and 0.1 µM and reduces AM secretion in HepG2 cells exposed to hypoxia[1][2].VULM1457 negatively regulates AM-induced cell proliferation[1].Pre-incubation of HepG2 cells with VULM 1457 at a concentration of 0.1 µM significantly reduced the total number of untouched affinity-specific [125I]AM binding found on the cells. Pre-incubation of HepG2 cells with VULM 1457 at high concentrations and at concentrations of 1.0 and 10.0 µM significantly altered AM binding properties[1].

VULM 1457 动物研究

Animal study VULM 1457 significantly reduced the atherogenic activity of experimental atherosclerosis in animals[1].VULM 1457 protects the heart of diabetic hypercholesterolaemic rats from ischaemia/reperfusion injury in vivo. Addition of VULM 1457 to a fat-cholesterol diet at a dose of 50 mg/kg/day administered for 5 days significantly reduced total cholesterol levels in plasma of diabetic-hypercholesterolaemic rats. The lipid-lowering effect of VULM 1457 was also observed in the liver of DM-HCH rats[2].

VULM 1457 参考文献

[1]J Drímal, et al. The ACAT inhibitor VULM1457 significantly reduced production and secretion of adrenomedullin (AM) and down-regulated AM receptors on human hepatoblastic cells. Gen Physiol Biophys. 2005 Dec;24(4):397-409.

[2]Adameová A, et al. The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA:cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and

VULM 1457 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.12mL

2.22mL

1.11mL

22.24mL

4.45mL

2.22mL

VULM 1457 技术信息

CAS号228544-65-8
分子式C25H27N3O3S
分子量 449.565
别名
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 250 mg/mL(556.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: VULM 1457 | 228544-65-8 | VULM1457 | VULM-1457 | Acyl-CoA Inhibitor | Metabolic Enzyme/Protease | Acyltransferase | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | VULM 1457 纯度/质量文件 | VULM 1457 亚型比较 | VULM 1457 生物活性 | VULM 1457 参考文献 | VULM 1457 实验方案 | VULM 1457 技术信息

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