ACAT inhibitor

Beauvericin 是一种镰刀菌毒素，能在大鼠肝微粒体酶实验中抑制酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 的活性，IC50 为 3 μM。

K-604 is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor. K-604 inhibits against acyl-coenzyme A (acyl-CoA):cholesterol O-acyltransferase-1 (ACAT1, SOAT1) activitiy in a selective (IC50 = 450 nM vs. 102.85 μ M against human ACAT1 and ACAT2, respectively) and acyl-CoA-competitive (Ki = 378 nM against oleoyl-coA) manner.

ACAT inhibitor

YM17E是一种酰基辅酶A:胆固醇酰基转移酶 (ACAT) 的抑制剂，在体外兔肝微粒体实验中具有显著的抑制活性，广泛用于胆固醇代谢及心血管疾病的研究。

RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

Glabrol是从甘草根的乙醇提取物中分离出来的一种异戊二烯类黄酮，是一种有效且非竞争性的 ACAT（酰基辅酶 A：胆固醇酰基转移酶）抑制剂，对大鼠肝脏微粒体 ACAT 的 IC50 为 24.6 μM。