Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17; TACE) Inhibitors, MMP-1 (Interstitial Collagenase) Inhibitors, MMP-13 (Collagenase 3) Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-7 (Matrilysin) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | MMP ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Marimastat |
+++
MMP-7, IC50: 16 nM MMP-14, IC50: 3 nM |
98% | |||||||||||||||||
Ilomastat |
++++
MMP-26, Ki: 0.36 nM MMP-2, Ki: 0.1 nM |
99%+ | |||||||||||||||||
SB-3CT |
+
MMP-9, Ki: 600 nM MMP-2, Ki: 13.9 nM |
99%+ | |||||||||||||||||
Doxycycline | ✔ | 98% | |||||||||||||||||
NSC 405020 | ✔ | 98% | |||||||||||||||||
Batimastat |
+++
MMP-1, IC50: 3 nM MMP-7, IC50: 4 nM |
99%+ | |||||||||||||||||
Nobiletin | ✔ | 98% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | TMI-1 is an effective inhibitor of ADAM17 and other MMPs. It suppresses the secretion of TNF-α induced by LPS in human primary monocytes and human whole blood[1]. TMI-1 selectively induces caspase-dependent apoptosis in triple-negative and ERBB2 overexpressing breast cancer cell lines[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.51mL 0.50mL 0.25mL |
12.55mL 2.51mL 1.25mL |
25.09mL 5.02mL 2.51mL |
CAS号 | 287403-39-8 |
分子式 | C17H22N2O5S2 |
分子量 | 398.497 |
别名 | WAY-171318 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,Store in freezer, under -20°C |
溶解度 |
DMSO: 105 mg/mL(263.49 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |