Ambeed.cn

首页 / / / / TAS-301

TAS-301 {[allProObj[0].p_purity_real_show]}

货号:A200976 Ambeed 开学季,买赠积分,赢豪礼

TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.

TAS-301 化学结构 CAS号:193620-69-8
TAS-301 化学结构
CAS号:193620-69-8
TAS-301 3D分子结构
CAS号:193620-69-8
TAS-301 化学结构 CAS号:193620-69-8
TAS-301 3D分子结构 CAS号:193620-69-8
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

TAS-301 纯度/质量文件 产品仅供科研

货号:A200976 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

JACS Au, 2024. Ambeed. [ A148168 ]
JMC, 2024. Ambeed. [ A187643 ]
JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]
Biomacromolecules, 2024. Ambeed. [ A110759 ]
Biomacromolecules, 2024. Ambeed. [ A203543 ]
更多 >
产品名称 ALK1 ALK2 ALK3 ALK4 ALK6 Smad3 TGF-β TGFβRI/ALK5 TGFβRII 其他靶点 纯度
LDN193189 ++++

ALK1, IC50: 0.8 nM

++++

ALK2, IC50: 0.8 nM

+++

ALK3, IC50: 5.3 nM

+++

ALK6, IC50: 16.7 nM

{[allProObj[0].p_purity_real_show]}
LDN-212854 ++++

ALK1, IC50: 2.4 nM

++++

ALK2, IC50: 1.3 nM

+

ALK3, IC50: 85.8 nM

+

ALK4, IC50: 2133 nM

+

ALK5, IC50: 9276 nM

{[allProObj[0].p_purity_real_show]}
ML347 ++

ALK1, IC50: 46 nM

++

ALK2, IC50: 32 nM

{[allProObj[0].p_purity_real_show]}
K02288 ++++

ALK1, IC50: 1.8 nM

++++

ALK2, IC50: 1.1 nM

++

ALK3, IC50: 34.4 nM

+++

ALK6, IC50: 6.4 nM

{[allProObj[0].p_purity_real_show]}
LDN-193189 dihydrochloride ++++

ALK1, IC50: 0.8 nM

++++

ALK2, IC50: 0.8 nM

+++

ALK3, IC50: 5.3 nM

+++

ALK6, IC50: 16.7 nM

{[allProObj[0].p_purity_real_show]}
LDN-214117 ++

ALK2, IC50: 24 nM

{[allProObj[0].p_purity_real_show]}
DMH-1 +

ALK2, IC50: 107.9 nM

{[allProObj[0].p_purity_real_show]}
SB-505124 +

ALK4, IC50: 129 nM

++

ALK5, IC50: 47 nM

{[allProObj[0].p_purity_real_show]}
Vactosertib +++

ALK4, IC50: 13 nM

+++

ALK5, IC50: 11 nM

{[allProObj[0].p_purity_real_show]}
Alantolactone {[allProObj[0].p_purity_real_show]}
SIS3 {[allProObj[0].p_purity_real_show]}
Pirfenidone {[allProObj[0].p_purity_real_show]}
Hesperetin {[allProObj[0].p_purity_real_show]}
RepSox ++++

TGFβR1(ALK5), IC50: 4 nM

{[allProObj[0].p_purity_real_show]}
GW788388 +++

ALK5, IC50: 18 nM

{[allProObj[0].p_purity_real_show]}
LY364947 ++

TGFβRI, IC50: 59 nM

+

TGFβRII, IC50: 0.4 μM

{[allProObj[0].p_purity_real_show]}
SD-208 ++

TGF-βRI (ALK5), IC50: 48 nM

{[allProObj[0].p_purity_real_show]}
SB-525334 +++

TGFβR1(ALK5), IC50: 14.3 nM

{[allProObj[0].p_purity_real_show]}
LY2109761 ++

TβRI, Ki: 38 nM

+

TβRII, Ki: 300 nM

{[allProObj[0].p_purity_real_show]}
Galunisertib ++

TβRI, IC50: 56 nM

{[allProObj[0].p_purity_real_show]}
SB 431542 +

ALK5, IC50: 94 nM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 PKC PKCα PKCβ PKCγ PKCδ PKCε PKCζ PKCη PKCθ 其他靶点 纯度
Daphnetin +

PKC, IC50: 25.01 μM

PKA,EGFR {[allProObj[0].p_purity_real_show]}
Dequalinium Chloride {[allProObj[0].p_purity_real_show]}
Quercetin Src,Sirtuin {[allProObj[0].p_purity_real_show]}
Myricetrin {[allProObj[0].p_purity_real_show]}
Go 6983 +++

PKCα, IC50: 7 nM

+++

PKCβ, IC50: 7 nM

+++

PKCγ, IC50: 6 nM

+++

PKCδ, IC50: 10 nM

++

PKCζ, IC50: 60 nM

{[allProObj[0].p_purity_real_show]}
Go6976 +++

PKC, IC50: 7.9 nM

++++

PKCα, IC50: 2.3 nM

+++

PKCβ1, IC50: 6.2 nM

FLT3 {[allProObj[0].p_purity_real_show]}
Bisindolylmaleimide I +++

PKCα, IC50: 20 nM

+++

PKCβ1, IC50: 17 nM

PKCβ2, IC50: 16 nM

+++

PKCγ, IC50: 20 nM

{[allProObj[0].p_purity_real_show]}
Lawsone methyl ether {[allProObj[0].p_purity_real_show]}
Sotrastaurin ++++

PKCα, Ki: 0.95 nM

++++

PKCβ1, Ki: 0.64 nM

++++

PKCδ, Ki: 2.1 nM

++++

PKCε, Ki: 3.2 nM

++++

PKCη, Ki: 1.8 nM

++++

PKCθ, Ki: 0.22 nM

{[allProObj[0].p_purity_real_show]}
Enzastaurin ++

PKCα, IC50: 39 nM

+++

PKCβ, IC50: 6 nM

+

PKCγ, IC50: 83 nM

+

PKCε, IC50: 110 nM

{[allProObj[0].p_purity_real_show]}
Midostaurin ++

PKCα, IC50: 22 nM

++

PKCβ1, IC50: 30 nM

PKCβ2, IC50: 31 nM

++

PKCγ, IC50: 24 nM

+

PKCδ, IC50: 330 nM

+

PKCε, IC50: 1.25 μM

+

PKCη, IC50: 160 nM

{[allProObj[0].p_purity_real_show]}
Ro 31-8220 mesylate ++++

PKCα, IC50: 5 nM

+++

PKCβ1, IC50: 24 nM

PKCβ2, IC50: 14 nM

++

PKCγ, IC50: 27 nM

++

PKCε, IC50: 24 nM

{[allProObj[0].p_purity_real_show]}
Staurosporine ++++

PKCα, IC50: 2 nM

++++

PKCγ, IC50: 5 nM

+++

PKCδ, IC50: 20 nM

++

PKCε, IC50: 73 nM

++++

PKCη, IC50: 4 nM

{[allProObj[0].p_purity_real_show]}
Ruboxistaurin HCl +

PKCα, IC50: 0.36 μM

++++

PKCβ1, IC50: 4.7 nM

PKCβ2, IC50: 5.9 nM

+

PKCγ, IC50: 0.3 μM

+

PKCδ, IC50: 0.25 μM

++

PKCη, IC50: 0.052 μM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

TAS-301 生物活性

描述 TAS-301 inhibits PKC activation and Ca2+ influx in a concentration-dependent manner, induced by PDGF, achieving 62.7% inhibition at 10 μM. It also reduces PMA-induced AP-1 activity, with 38% and 67.6% inhibition at concentrations of 3 and 10 μM, respectively[1]. Dose-dependently, TAS-301 (0.3-3 μM) curtails cell migration induced by various growth factors (PDGF-BB, IGF-1, HB-EGF) and diminishes bFGF-induced BrdU incorporation, particularly at 3 and 10 μM[2].
体内研究

Administered orally at doses ranging from 3 to 100 mg/kg, TAS-301 dose-dependently mitigates neointimal thickening and the intima/media (I/M) ratio, alongside reducing the level of intimal cells in rat models 14 days following balloon injury[2].

体外研究

TAS-301 inhibits PKC activation and Ca2+ influx in a concentration-dependent manner, induced by PDGF, achieving 62.7% inhibition at 10 μM. It also reduces PMA-induced AP-1 activity, with 38% and 67.6% inhibition at concentrations of 3 and 10 μM, respectively[1].

Dose-dependently, TAS-301 (0.3-3 μM) curtails cell migration induced by various growth factors (PDGF-BB, IGF-1, HB-EGF) and diminishes bFGF-induced BrdU incorporation, particularly at 3 and 10 μM[2].

TAS-301 参考文献

[1]Muranaka Y, et al. TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. J Pharmacol Exp Ther. 1998 Jun;285(3):1280-6.

[2]Sasaki E, et al. TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor. Jpn J Pharmacol. 2000 Nov;84(3):252-8.

TAS-301 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.80mL

0.56mL

0.28mL

13.99mL

2.80mL

1.40mL

27.98mL

5.60mL

2.80mL

TAS-301 技术信息

CAS号193620-69-8
分子式C23H19NO3
分子量 357.4
别名
运输蓝冰
存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 40 mg/mL(111.92 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。