Stigmasterol, a natural compound isolated from Azadirachta indica, has many biological activities. In vitro studies, stigmasterol could induce apoptosis in hepatocarcimona (HepG2) cells by regulating the expression of some special genes. Besides this, it was found that stigmasterol could inhibit the activity of a partially purified bloodstream T. congolense sialidase with an inhibition binding constant of 356.59 μM. In vivo studies, stigmasterol could contribute to the improvement of skin tumors induced by 7,12-dimethylbenz[a]anthracene in swiss albino mice, possibly because of its oxidative stress response. In addition, stigmasterol has the ability of relieving some special skin inflammatory features in rodents.
China
... 展开 >> Anzhen Hospital, Capital University of Medical Sciences
Beijing, China
Chao Yang 2nd Hospital
Beijing, China
Chui Yang Liu Hospital
Beijing, China 收起 <<
Withdrawn(This study was combi... 展开 >>ned with another CIHR funded study (NCT02078635). Both studies involve the same dietary portfolio and the same study population.) 收起 <<
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Canada, British Columbia
... 展开 >>
Healthy Heart Lipid Clinic, St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Canada, Manitoba
Richardson Center for Functional Foods and Nutraceuticals and the St. Boniface Hospital Cardiovascular Center, University of Manitoba
Winnipeg, Manitoba, Canada, R3T 6C5
Canada, Ontario
Risk Factor Modification Centre, St. Michael's Hospital
Toronto, Ontario, Canada, M5C 2T2
Canada, Quebec
Institute of Nutraceuticals and Functional Foods and the Quebec Heart and Lung Institute, Laval University
Quebec City, Quebec, Canada, G1V 4G2 收起 <<
Canada, British Columbia
... 展开 >>
Healthy Heart Lipid Clinic, St. Paul's Hospital
Recruiting
Vancouver, British Columbia, Canada, V6Z 1Y6
Principal Investigator: Jiri Frohlich, MD
Canada, Manitoba
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba
Not yet recruiting
Winnipeg, Manitoba, Canada, R3T 6C5
Contact: Peter Jones, PhD
Principal Investigator: Peter Jones, PhD
Canada, Ontario
Risk Factor Modification Centre, St. Michael's Hospital
Recruiting
Toronto, Ontario, Canada, M5C 2T2
Contact: David J Jenkins, MD PhD 416-867-7475 David.jenkins@utoronto.ca
Contact: Dorothea A Faulkner, PhD 416-360-4000 ext 48175 FaulknerD@smh.ca
Principal Investigator: David J Jenkins, MD PhD
Sub-Investigator: Cyril Kendall, PhD
Sub-Investigator: Robert Josse, MD
Sub-Investigator: Lawrence Leiter, MD
Sub-Investigator: John Sievenpiper, MD PhD
Sub-Investigator: Anish Kirpalani, MD
Canada, Quebec
Institute of Nutraceuticals and Functional Foods, Laval University
Recruiting
Quebec City, Quebec, Canada, G1V 4G2
Contact: Benoit Lamarche, PhD
Principal Investigator: Benoit Lamarche, PhD 收起 <<
Canada, Ontario
... 展开 >>
The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Micheal's Hospital
Toronto, Ontario, Canada, M5C 2T2 收起 <<
Canada, British Columbia
... 展开 >>
Healthy Heart Program, St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Canada, Manitoba
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba
Winnipeg, Manitoba, Canada, R3T 6C5
Canada, Ontario
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
St. Michael's Hospital
Toronto, Ontario, Canada, M5C 2T2
Canada, Quebec
Institute on Nutraceuticals and Functional Foods and the Lipid Research Center, Laval University Hospital Research Center
Quebec City, Quebec, Canada, G1V 4G2 收起 <<
Withdrawn(Study was amalgamate... 展开 >>d with another study to include exercise as another intervention.) 收起 <<
-
Canada, British Columbia
... 展开 >>
Healthy Heart Lipid Clinic, St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Canada, Manitoba
Richardson Center for Functional Foods and Nutraceuticals and the St. Boniface Hospital Cardiovascular Center, University of Manitoba
Winnipeg, Manitoba, Canada, R3T 6C5
Canada, Ontario
Risk Factor Modification Centre, St. Michael's Hospital
Toronto, Ontario, Canada, M5C 2T2
Canada, Quebec
Institute of Nutraceuticals and Functional Foods and the Quebec Heart and Lung Institute, Laval University
Quebec City, Quebec, Canada, G1V 4G2 收起 <<
United States, Pennsylvania
... 展开 >>
Abington Memorial Hospital
Abington, Pennsylvania, United States
Chestnut Hill Hospital
Philadelphia, Pennsylvania, United States, 19118 收起 <<
Chile
... 展开 >> Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile
Santiago, Región Metropolitana de Santiago, Chile
Department of Nutrition, Diabetes and Metabolism. Pontificia Universidad Catolica de Chile
Santiago, Chile 收起 <<
Canada, Manitoba
... 展开 >>
Department of Human Nutritional sciences, University of Manitoba
Recruiting
Winnipeg, Manitoba, Canada, R3T2N2
Contact: James House, PhD 204-474-6837 james.house@umanitoba.ca
Principal Investigator: James House, PhD 收起 <<
Finland
... 展开 >> Department of Medicine, Div. of Internal Medicine, Helsinki Univ. Central Hospital (HUCH)
Recruiting
Helsinki, Finland, 00029HUS
Contact: Markku Nissinen, MD, PhD +358 9 4711 markku.nissinen@hus.fi
Principal Investigator: Tatu A Miettinen, Professor
Sub-Investigator: Markku J Nissinen, MD, PhD 收起 <<
Terminated(Recruitment and org... 展开 >>anizational difficulties) 收起 <<
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France
... 展开 >> Hôpital cardio-vasculaire et pneumologique Louis Pradel
Bron, France, 69677
Clinique d'Endocrinologie, Maladies Métaboliques et Nutrition
Nantes, France, 44093
Groupe Hospitalier Pitié-Salpêtrière, Endocrinology and Metabolism Department
Paris, France, 75013 收起 <<
United States, Louisiana
... 展开 >>
Pennington Biomedical Research Center-Louisana State University System
Baton Rouge, Louisiana, United States, 70808 收起 <<
Netherlands
... 展开 >> Maastricht University Medical Centre
Recruiting
Maastricht, Limburg, Netherlands, 6229 ER
Contact: Sabine Baumgartner, Dr. +31 (0)43 3881305 sabine.baumgartner@maastrichtuniversity.nl 收起 <<
Thailand
... 展开 >> Mahidon University, Nutrition Institute, Center of Innovation and Reference on Food for Nutrition (CIRFON)
Phutthamonthon, Nakhon Pathom, Thailand, 73170 收起 <<
United States, Maryland
... 展开 >>
USDA-ARS, Beltsville Human Nutrition Research Center
Beltsville, Maryland, United States, 20705
Canada, Manitoba
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba
Winnipeg, Manitoba, Canada, R3T 6C5 收起 <<
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