产品说明书
Stigmasterol
 |
同义名 : | Stigmasterin;5,22-Cholestadien-24-beta-ethyl-3-beta-ol |
| CAS号 : | 83-48-7 | |
| 货号 : | A284575 | |
| 分子式 : | C29H48O | |
| 纯度 : | 95% | |
| 分子量 : | 412.691 | |
| MDL号 : | MFCD00003630 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMF: 1 mg/mL(2.42 mM)，配合低频超声，并水浴加热至45℃助溶 |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Stigmasterol, a natural compound isolated from Azadirachta indica, has many biological activities. In vitro studies, stigmasterol could induce apoptosis in hepatocarcimona (HepG2) cells by regulating the expression of some special genes. Besides this, it was found that stigmasterol could inhibit the activity of a partially purified bloodstream T. congolense sialidase with an inhibition binding constant of 356.59 μM. In vivo studies, stigmasterol could contribute to the improvement of skin tumors induced by 7,12-dimethylbenz[a]anthracene in swiss albino mice, possibly because of its oxidative stress response. In addition, stigmasterol has the ability of relieving some special skin inflammatory features in rodents. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00698256 | Hypercholesterolemia | Not Applicable | Completed | - | Finland ... 展开 >> University of kuopio Kuopio, Finland, 70211 收起 << |
| NCT02702947 | BPH | Phase 4 | Completed | - | India ... 展开 >> Department of Urology, King George's Medical University, Lucknow, UP, India Lucknow, Uttar Pradesh, India, 226003 收起 << |
| NCT00718796 | Cardiovascular Disease | Phase 3 | Completed | - | Canada, Ontario ... 展开 >> Canadian College of Naturopathic Medicine Toronto, Ontario, Canada, M2K 1E2 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.42mL 0.48mL 0.24mL |
12.12mL 2.42mL 1.21mL |
24.23mL 4.85mL 2.42mL |
| 参考文献 |
|---|