货号：A126336同义名：
维生素A酸
/ Vitamin A acid;all-trans-Retinoic acid
Retinoic acid (Vitamin A acid)作为 RAR 核受体的激动剂，用于细胞疗法中的辅助试剂。
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Retinoic acid receptors (RARs) are members of the super‐family of nuclear hormone receptors, which directly regulate the transcription of their target genes in the nucleus. Retinoic acid, the active metabolite of vitamin A, is a ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR). It has pleiotropic effects on growth, differentiation, proliferation, and development, and determines embryonic pattern formation and inhibits tumor growth. Addition of tretinoin significantly suppressed the remarkably elevated MMP-13 mRNA expression in the keloid‐derived dermal fibroblasts, with the peak suppression at 12h[3]. Tretinoin also prevented the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content in dose- and time-dependent manner[4]. Retinoic acid at 10 μM inhibited the migration of Aspc-1 and Panc-1 cells indirectly through its inhibitory effects on cancer associated fibroblasts (CAFs) and inhibited epithelial-mesenchymal transition of tumor cells by decreasing IL-6 secretion of CAFs[5]. Neural stem cells (NSCs) treated with 1 µM retinoic acid for 4 days showed increased HRas and Tuj1 levels together with the increase in the active HRas level, which was required for NSC differentiation into neurons and murine brain development[6].
Retinoic acid 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
COS7 cells
Function assay
16 h
Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay, EC50=0.0002 μM
维生素A酸
;Vitamin A acid;all-trans-Retinoic acid;ATRA;Vitinoin;StievaA Forte;StievaA;RetisolA;Eudyna;EpiAberel;Dermairol;RetinA MICRO;RetinA;Renova;Avita;Aknoten;Vitamin A Acid. US brand names: Aberel;tretinoinum;trans vitamin A acid;trans retinoic acid;TRA;betaretinoic acid;alltrans vitamin A acid;RA;NSC 122758;NSC 122578;Tretinoin
运输
蓝冰
存储条件
液体-20°C:3-6个月-80°C:12个月
粉末Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay, EC50=0.0002 μM
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