Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM[3]. Rabeprazole is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity used in the therapy of gastroesophageal reflux and peptic ulcer disease[4]. Rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 (extracellular signal-regulated protein kinase 1/2) signaling pathway[5]. Femurs from mice received rabeprazole showed widely separated, thin-walled bone trabeculae and increased number of osteoclasts[6]. In human studies, once-daily doses of 5-40 mg of rabeprazole inhibit gastric acid secretion in a dose-dependent fashion[7].
Hong Kong
... 展开 >> Prince of Wales Hospital
Hong Kong, Hong Kong
Japan
Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan
Izumo, Japan
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Kyoto, Japan
Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan (Satellite hospital of Osaka City University)
Osaka, Japan
Department of Gastroenterology, Osaka City University Graduate School of Medicine
Osaka, Japan
Department of Gastroenterology, Takarazuka Municipal Hospital, Hyogo, Japan (Satellite hospital of Osaka City University)
Osaka, Japan
Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
Osaka, Japan
Department of Internal Medicine and Gastroenterology, Saga Medical School, Saga, Japan
Saga, Japan 收起 <<
United States, Washington
... 展开 >>
ASTHMA, Inc.
Richland, Washington, United States, 99352
ASTHMA, Inc.
Seattle, Washington, United States, 98105 收起 <<
United States, Florida
... 展开 >>
MRA Clinical Research - Phase 1
Miami, Florida, United States, 33143
Miami Research Associates, LLC
South Miami, Florida, United States, 33143
MRA Clinical Research, LLC
South Miami, Florida, United States, 33143 收起 <<
Japan
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Nagoya, Aichi, Japan
Chikushino, Fukuoka, Japan
Kitakyushu, Fukuoka, Japan
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Oita, Japan
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Saga, Japan
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Shizuoka, Japan
Yamagata, Japan 收起 <<
Japan
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Nagoya, Aichi, Japan
Hirosaki, Aomori, Japan
Kashiwa, Chiba, Japan
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Fukuyama, Hiroshima, Japan
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Kobe, Hyogo, Japan
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Sendai, Miyagi, Japan
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Yufu, Oita, Japan
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Osaka, Japan
Saga, Japan
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Toyama, Japan
Yamaguchi, Japan 收起 <<
United States, Arizona
... 展开 >>
GSK Investigational Site
Goodyear, Arizona, United States, 85338
United States, Texas
GSK Investigational Site
Dallas, Texas, United States, 75201
United States, Washington
GSK Investigational Site
Tacoma, Washington, United States, 98405
Australia, Victoria
GSK Investigational Site
Heidelberg, Victoria, Australia, 3084
GSK Investigational Site
Melbourne, Victoria, Australia, 3004
United Kingdom
GSK Investigational Site
London, United Kingdom, W1G 6AD 收起 <<
Australia
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Belconnen, Australia
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Japan
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Kariya, Aichi, Japan
Nagoya, Aichi, Japan
Seto, Aichi, Japan
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Hiroshima, Japan
Kouchi, Japan
Kyoto, Japan
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Oita, Japan
Saga, Japan 收起 <<
United States, Arkansas
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Little Rock, Arkansas, United States
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