产品说明书
Rabeprazole Sodium Salt
 |
同义名 : | 雷贝拉唑钠盐 ;LY307640 sodium;Rabeprazole (sodium salt);dexrabeprazole;3810, E;Rebeprazole sodium;Aciphex;Pariet;LY307640;E 3810;Habeprazole Sodium;Dexrabeprazole Sodium;Aciphex Sodium;Rabeprazole sodium |
| CAS号 : | 117976-90-6 | |
| 货号 : | A101729 | |
| 分子式 : | C18H20N3NaO3S | |
| 纯度 : | 98% | |
| 分子量 : | 381.425 | |
| MDL号 : | MFCD02092688 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(275.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 65 mg/mL(170.41 mM)，配合低频超声，并调节pH至11 |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM[3]. Rabeprazole is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity used in the therapy of gastroesophageal reflux and peptic ulcer disease[4]. Rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 (extracellular signal-regulated protein kinase 1/2) signaling pathway[5]. Femurs from mice received rabeprazole showed widely separated, thin-walled bone trabeculae and increased number of osteoclasts[6]. In human studies, once-daily doses of 5-40 mg of rabeprazole inhibit gastric acid secretion in a dose-dependent fashion[7]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00234117 | Bronchial Asthma ... 展开 >> Gastroesophageal Reflux 收起 << | Not Applicable | Completed | - | Puerto Rico ... 展开 >> Ponce Gastroentrology Research Ponce, Puerto Rico, 00717 收起 << |
| NCT01237353 | Pharmacodynamic | Not Applicable | Completed | - | United States, California ... 展开 >> University of California San Francisco San Francisco, California, United States, 94143 收起 << |
| NCT01237353 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.62mL 0.52mL 0.26mL |
13.11mL 2.62mL 1.31mL |
26.22mL 5.24mL 2.62mL |
| 参考文献 |
|---|
|
[1]Yamasaki Y, et al. Biomed Rep. 2016, 5(1):118-124. |