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前列腺素E2 /Prostaglandin E2 {[allProObj[0].p_purity_real_show]}

货号:A695566 同义名: 地诺前列酮 / PGE2;Dinoprostone

Prostaglandin E2 is a natural prostaglandin and acts as a vasodilator by activating the prostaglandin E2 receptor.

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Prostaglandin E2 化学结构 CAS号:363-24-6
Prostaglandin E2 化学结构
CAS号:363-24-6
Prostaglandin E2 3D分子结构
CAS号:363-24-6
Prostaglandin E2 化学结构 CAS号:363-24-6
Prostaglandin E2 3D分子结构 CAS号:363-24-6
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Prostaglandin E2 纯度/质量文件 产品仅供科研

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Prostaglandin E2 生物活性

描述 Prostaglandin E2 (PGE2) is a potent inflammatory mediator that is generated by cyclooxygenase 2 (COX2) conversion of arachidonic acid. PGE2 was shown to stimulate progenitor proliferation in vitro in cell culture and intravenous injection of PGE on injured mice showed significant improvement in marrow recovery versus control animals[3]. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction[4].

Prostaglandin E2 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00791323 - Completed - -
NCT00347503 Cataract Phase 4 Completed - United States, Pennsylvania ... 展开 >> Bucci Laser Vision Wilkes Barre, Pennsylvania, United States, 18702 收起 <<
NCT03507621 - Active, not recruiting December 15, 2018 Turkey ... 展开 >> Kahramanmaras Sutcu Imam Univercity Faculty of edicine Kahramanmaraş, Onikişubat, Turkey, 251/A 46040 收起 <<

Prostaglandin E2 参考文献

[1]Shen L, Liu Y. Prostaglandin E2 blockade enhances the pulmonary anti-Cryptococcus neoformans immune reaction via the induction of TLR-4. Int Immunopharmacol. 2015 Sep;28(1):376-81.

[2]Melin E, Lindroos E, et al. Elevated expression of prostaglandin E2 synthetic pathway in skeletal muscle of prior polio patients. J Rehabil Med. 2014 Jan;46(1):67-72.

[3]Lord AM, North TE, Zon LI. Prostaglandin E2: making more of your marrow. Cell Cycle. 2007;6(24):3054-3057.

[4]Haylor J, Towers J. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982;76(1):131-137.

Prostaglandin E2 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.84mL

0.57mL

0.28mL

14.19mL

2.84mL

1.42mL

28.37mL

5.67mL

2.84mL

Prostaglandin E2 技术信息

CAS号363-24-6
分子式C20H32O5
分子量 352.47
别名 地诺前列酮 ;PGE2;Dinoprostone
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(297.9 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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