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Prostaglandin E2

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Chemical Structure| 363-24-6 同义名 : 地诺前列酮 ;PGE2;Dinoprostone
CAS号 : 363-24-6
货号 : A695566
分子式 : C20H32O5
纯度 : 98%
分子量 : 352.47
MDL号 : MFCD00077861
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(297.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Prostaglandin E2 (PGE2) is a potent inflammatory mediator that is generated by cyclooxygenase 2 (COX2) conversion of arachidonic acid. PGE2 was shown to stimulate progenitor proliferation in vitro in cell culture and intravenous injection of PGE on injured mice showed significant improvement in marrow recovery versus control animals[3]. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00791323 - Completed - -
NCT00347503 Cataract Phase 4 Completed - United States, Pennsylvania ... 展开 >> Bucci Laser Vision Wilkes Barre, Pennsylvania, United States, 18702 收起 <<
NCT03507621 - Active, not recruiting December 15, 2018 Turkey ... 展开 >> Kahramanmaras Sutcu Imam Univercity Faculty of edicine Kahramanmaraş, Onikişubat, Turkey, 251/A 46040 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.84mL

0.57mL

0.28mL

14.19mL

2.84mL

1.42mL

28.37mL

5.67mL

2.84mL
参考文献

[1]Shen L, Liu Y. Prostaglandin E2 blockade enhances the pulmonary anti-Cryptococcus neoformans immune reaction via the induction of TLR-4. Int Immunopharmacol. 2015 Sep;28(1):376-81.

[2]Melin E, Lindroos E, et al. Elevated expression of prostaglandin E2 synthetic pathway in skeletal muscle of prior polio patients. J Rehabil Med. 2014 Jan;46(1):67-72.

[3]Lord AM, North TE, Zon LI. Prostaglandin E2: making more of your marrow. Cell Cycle. 2007;6(24):3054-3057.

[4]Haylor J, Towers J. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982;76(1):131-137.