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全部(267) Agonist(12) Antagonist(11) Inhibitor(3) Activator(2)
EP1-antagonist-1是一种 EP1 受体的拮抗剂,具有显著的抑制作用,pKi 为 7.54,pIC50 为 8.5,适用于疼痛和炎症相关的研究。
Carboprost tromethamine是前列腺素 F2α (prostaglandin F2α)的 15 甲基类似物,能够有效促进子宫规律性收缩,用于减少产后出血,适用于产科紧急情况下的应用。
p-Hydroxy-cinnamic acid is the isomer of cinnamic acid with anti-mutagenic and anti-tumor activities.
Ralinepag, is an orally available agonist of the prostacyclin (IP) receptor.
AM211 is a potent and selective prostaglandin D2 receptor type 2 antagonist with IC50 value of 4.9nM.
AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors.
E7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4. It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.
MF-766是一种高效的 EP4 拮抗剂,能特异性地阻断 EP4 受体信号传导。它在癌症和炎症相关疾病研究中展现了良好的治疗潜力。
Limaprost is a PGE1 analog and potent platelet adhesion inhibitor.
Taprenepag is an agonist of prostaglandin E2 receptor with EC50 of 2.8 nM with hypotensive activity.
Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM).
Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.
BI-671800是一种前列腺素 D2 受体 (DP2/CRTH2) 拮抗剂,能够抑制过敏反应。它在哮喘和其他过敏性疾病研究中展现出良好的应用前景。
EP2 receptor antagonist-2 (CID891729)是一种EP2受体拮抗剂,能够抑制PGE2诱导的EP2受体激活,并且抑制N-甲基-D-天冬氨酸 (NMDA) 诱导的乳酸脱氢酶 (LDH) 释放。
Tafluprost is an anti-glaucoma prostaglandin (PG) analog.
Picotamide是一种血栓素 A2 合成酶和受体的联合抑制剂,具有抗血小板活性,在糖尿病中可减少微量白蛋白尿并抑制颈动脉斑块的生长,适用于急性或慢性心血管疾病研究。
Genz-123346 free base is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1 and IC50 for GM1 inhibition is 14 nM.
TG4-155是一种有效的穿脑选择性EP2受体拮抗剂,其Ki为9.9 nM。TG4-155仅对EP2和DP1受体显示低纳摩尔级别的拮抗活性。TG4-155对EP2的KB为2.4 nM,显示出对DP1受体的14倍选择性,对EP1、EP3、EP4和IP受体的选择性为550-4750倍。
Dinoprost tromethamine is a natural prostaglandin used as an abortifacient.
Travoprost is a synthetic prostaglandin F2α analog as a potent and selective FP prostaglandin receptor agonist, used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure.
Tags: 前列腺素受体 | Prostaglandin Receptor | G蛋白偶联受体/G蛋白 | GPCR/G Protein | 前列腺素受体 相关产品
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