Phellodendrine HCl, a natural product isolated and purified from the cortex Phellodendri chinensis with anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. Phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway.
Phellodendrine HCl, an isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendri chinensis cortex. Phellodendrine inhibited AChE activity in a dose-dependent manner with IC50 of 36.51 μM[2]. Phellodendrine, but not berberine, exhibited antioxidant activity by increasing radical scavenging activity. Phellodendrine may promote autophagy by regulating the AMPK-mTOR signalling pathway, thereby reducing intestinal injury due to UC(ulcerative colitis)[3]. And PHE (Phellodendrine) exerted the protective activity against AAPH-induced oxidative stress through down-regulating AKT phosphorylation and NF-kB3 expression, which associate with modulation of IKK phosphorylation in zebrafish embryos[4].
搜索
