产品说明书

Phellodendrine chloride

Print
Chemical Structure| 104112-82-5 同义名 : Phellodendrine (chloride)
CAS号 : 104112-82-5
货号 : A696868
分子式 : C20H24ClNO4
纯度 : 98%
分子量 : 377.862
MDL号 : MFCD01732398
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(132.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Phellodendrine HCl, an isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendri chinensis cortex. Phellodendrine inhibited AChE activity in a dose-dependent manner with IC50 of 36.51 μM[2]. Phellodendrine, but not berberine, exhibited antioxidant activity by increasing radical scavenging activity. Phellodendrine may promote autophagy by regulating the AMPK-mTOR signalling pathway, thereby reducing intestinal injury due to UC(ulcerative colitis)[3]. And PHE (Phellodendrine) exerted the protective activity against AAPH-induced oxidative stress through down-regulating AKT phosphorylation and NF-kB3 expression, which associate with modulation of IKK phosphorylation in zebrafish embryos[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.65mL

0.53mL

0.26mL

13.23mL

2.65mL

1.32mL

26.46mL

5.29mL

2.65mL
参考文献

[1]Jiang XY, Zhang HF, et al. [ILs-HPLC simultanesous determination of five alkaloids in phellodenddri chinensis cortex] . Zhongguo Zhong Yao Za Zhi. 2014 Oct;39(19):3808-12. Chinese.

[2]Kim YJ, Lim HS, Kim Y, Lee J, Kim BY, Jeong SJ. Phytochemical Quantification and the In Vitro Acetylcholinesterase Inhibitory Activity of Phellodendron chinense and Its Components. Molecules. 2017 Jun 2;22(6):925

[3]Su S, Wang X, Xi X, Zhu L, Chen Q, Zhang H, Qin Y, Yang B, Che N, Cao H, Zhong W, Wang B. Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis. J Cell Mol Med. 2021 Jun;25(12):5707-5720

[4]Li L, Huang T, Tian C, Xiao Y, Kou S, Zhou X, Liu S, Ye X, Li X. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos. Life Sci. 2016 Jul 15;157:97-106