Periplocin (PP) is a cardiotonic steroid isolated from Periploca forrestii (PF). Periplocin is the highest level of cardiotonic steroid included in PF. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase. Periplocin (5 - 20 μM; 48 hours; L929 cells) treatment shows increased proliferation up to 131% at 20 μM. It increases phosphorylation of Src, ERK, PI3K and Akt at active sites in a dosedependent and time-dependent manner. Periplocin (5 - 20 μM; 48 hours) significantly promotes migration of fibroblast cell and increases collagen production in L929 fibroblast. Periplocin induces Na/KATPase mediates the activation of Src/ERK and PI3K/Akt pathways[1]. In addition, intraperitoneal injection (IP) of periplocin repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice[2]. Periplocin inhibits the proliferation of gastric cancer cells and induces apoptosis in vitro and in vivo, indicating its potential to be used as an antitumor drug[3]. Periplocin led to growth inhibition and apoptosis induction by changing the expression of death receptors and inducing DNA double strand breaks in SW-872 cells[4].
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