产品说明书
Periplocin
 |
同义名 : | Periplocoside |
| CAS号 : | 13137-64-9 | |
| 货号 : | A705257 | |
| 分子式 : | C36H56O13 | |
| 纯度 : | 97% | |
| 分子量 : | 696.822 | |
| MDL号 : | MFCD01745141 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(150.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Periplocin (PP) is a cardiotonic steroid isolated from Periploca forrestii (PF). Periplocin is the highest level of cardiotonic steroid included in PF. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase. Periplocin (5 - 20 μM; 48 hours; L929 cells) treatment shows increased proliferation up to 131% at 20 μM. It increases phosphorylation of Src, ERK, PI3K and Akt at active sites in a dosedependent and time-dependent manner. Periplocin (5 - 20 μM; 48 hours) significantly promotes migration of fibroblast cell and increases collagen production in L929 fibroblast. Periplocin induces Na/KATPase mediates the activation of Src/ERK and PI3K/Akt pathways[1]. In addition, intraperitoneal injection (IP) of periplocin repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice[2]. Periplocin inhibits the proliferation of gastric cancer cells and induces apoptosis in vitro and in vivo, indicating its potential to be used as an antitumor drug[3]. Periplocin led to growth inhibition and apoptosis induction by changing the expression of death receptors and inducing DNA double strand breaks in SW-872 cells[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.44mL 0.29mL 0.14mL |
7.18mL 1.44mL 0.72mL |
14.35mL 2.87mL 1.44mL |
| 参考文献 |
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