There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Omeprazole sodium (H 16868 sodium), another form of this proton pump inhibitor, also targets acid-related gastrointestinal disorders and similarly inhibits CYP2C19 activity with a Ki of 2 to 6 μM[1]. This sodium salt form also restricts the growth of both Gram-positive and Gram-negative bacteria[2]. Omeprazole is a significant inhibitor of neutral sphingomyelinase (N-SMase), impacting brain pathways related to exosome production[3].
体外研究
For treating gastrointestinal disorders, Omeprazole (H 16868) has shown to significantly reduce intragastric acidity, with median 24-hour intragastric pH increasing from 1.4 to 5.3 and mean hourly hydrogen ion activity dropping from 38.50 to 1.95 mmol(mEq)/L, surpassing the effectiveness of cimetidine and ranitidine[1].
The pharmacokinetic behavior of omeprazole was evaluated in healthy male subjects who received either single or repeated doses of 30 and 60 mg. The absorption from its enteric-coated formula proved unpredictable, but a significant increase in the area under the plasma concentration-time curve (AUC) was observed after repeated doses, suggesting enhanced bioavailability, likely due to the compound's ability to inhibit its own gastric acid secretion[2].
Omeprazole sodium is a potent inhibitor of neutral sphingomyelinase (N-SMase), effectively penetrating the brain and impacting exosome regulation[3].
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