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Omeprazole sodium

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Chemical Structure| 95510-70-6 同义名 : H 16868 sodium
CAS号 : 95510-70-6
货号 : A208846
分子式 : C17H18N3NaO3S
纯度 : 98+%
分子量 : 367.398
MDL号 : MFCD07802816
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(326.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 5.5 mg/mL(14.97 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Omeprazole sodium (H 16868 sodium), another form of this proton pump inhibitor, also targets acid-related gastrointestinal disorders and similarly inhibits CYP2C19 activity with a Ki of 2 to 6 μM[1]. This sodium salt form also restricts the growth of both Gram-positive and Gram-negative bacteria[2]. Omeprazole is a significant inhibitor of neutral sphingomyelinase (N-SMase), impacting brain pathways related to exosome production[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.61mL

2.72mL

1.36mL

27.22mL

5.44mL

2.72mL
参考文献

[1]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7.

[2]Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50.

[3]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.