Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
抗生素和抗病毒 囊泡 肿瘤
/
抗感染
PI3K/Akt/mTOR 功能 外泌体 肿瘤生长增殖和凋亡
/
mTOR
驱虫剂 Antibacterial
/ Niclosamide Ethanolamine Salt

氯硝柳胺乙醇胺盐 /Niclosamide Ethanolamine Salt {[allProObj[0].p_purity_real_show]}

货号：A116636 同义名： Niclosamide olamine;BAY2353 olamine

Niclosamide Ethanolamine Salt是一种口服活性 P-糖蛋白 (Pgp) 和乳腺癌耐药蛋白 (BCRP) 抑制剂，用于研究外排转运蛋白对药物在脑中分布的影响，并用于癌症研究。

Niclosamide Ethanolamine Salt 化学结构 CAS号：1420-04-8
Niclosamide Ethanolamine Salt 化学结构
CAS号：1420-04-8
Niclosamide Ethanolamine Salt 3D分子结构
CAS号：1420-04-8
Niclosamide Ethanolamine Salt 化学结构 CAS号：1420-04-8
Niclosamide Ethanolamine Salt 3D分子结构 CAS号：1420-04-8
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Niclosamide Ethanolamine Salt 纯度/质量文件 产品仅供科研

货号：A116636 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]
• Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]
• ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]
• ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]
• Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]
更多 >
产品名称 mTOR ↓ mTORC1 ↓ mTORC2 ↓ 其他靶点 纯度
AZD-8055 ++++

mTOR (full length), IC50: 0.8 nM

mTOR (truncated), IC50: 0.13 nM

 		99%+
Gedatolisib ++++

mTOR, IC50: 1.6 nM

 		99%
GSK1059615 ++

mTOR, IC50: 12 nM

 		98%
Vistusertib +++

mTOR, IC50: 2.8 nM

 		99%+
Torin 1 +++

mTOR, IC50: 4.32 nM

 		+++

mTORC1, IC50: 2 nM

 		++

mTORC2, IC50: 10 nM

 		DNA-PK 99%+
Dactolisib +++

mTOR (p70S6K), IC50: 6 nM

 		98+%
PI-103 +

mTOR, IC50: 30 nM

 		99%+
WAY-600 ++

mTOR, IC50: 9 nM

 		99%
Voxtalisib +

mTOR, IC50: 157 nM

 		99%+
PF-04691502 ++

mTOR, Ki: 16 nM

 		98+%
Onatasertib ++

mTOR, IC50: 16 nM

 		DNA-PK 99%+
Chrysophanol ✔ EGFR 98%
Samotolisib ✔ DNA-PK 99%+
Torkinib +++

mTOR, IC50: 8 nM

 		PDGFR,DNA-PK 99%+
Everolimus 99%+
WYE-354 +++

mTOR, IC50: 5 nM

 		98%
Tacrolimus ✔ 98%
PP121 ++

mTOR, IC50: 13 nM

 		PDGFR,VEGFR 99%+
Torin 2 ++++

mTOR, IC50: 0.25 nM

 		DNA-PK 99%+
Rapamycin ++++

mTOR, IC50: ~0.1 nM

 		98%
GDC-0349 +++

mTOR, Ki: 3.8 nM

 		98%
XL388 ++

mTOR, IC50: 9.9 nM

 		+++

mTORC1, IC50: 8 nM

 		+

mTORC2, IC50: 166 nM

 		99%+
WYE-687 +++

mTOR, IC50: 7 nM

 		98+%
Apitolisib +

mTOR, Ki app: 17 nM

 		98%+
WYE-132 ++++

mTOR, IC50: 0.19 nM

 		99%+
Sapanisertib ++++

mTOR, Ki: 1.4 nM

 		99%+
BGT226 maleate ✔ 99%+
ETP-46464 ++++

mTOR, IC50: 0.6 nM

 		DNA-PK 98%
PI3K-IN-1 +

mTOR, IC50: 157 nM

 		98+%
Zotarolimus +++

FKBP-12, IC50: 2.8 nM

 		99+%
OSI-027 +++

mTOR, IC50: 4 nM

 		+

mTORC1, IC50: 22 nM

 		+

mTORC2, IC50: 65 nM

 		99%+
Ridaforolimus ++++

mTOR, IC50: 0.2 nM

 		99%+
Temsirolimus +

mTOR, IC50: 1.76 μM

 		95%
CZ415 ++

mTOR, pIC50: 8.07

 		99%+
SF2523 +

mTOR, IC50: 280 nM

 		DNA-PK 99%+
KU-0063794 ++

mTORC1, IC50: ~10 nM

 		++

mTORC2, IC50: ~10 nM

 		99%+
Omipalisib ++++

mTORC1, Ki: 0.18 nM

 		++++

mTORC2, Ki: 0.3 nM

 		99%+
Palomid 529 ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Niclosamide Ethanolamine Salt 生物活性

描述 Niclosamide olamine, another form of the drug, retains the same oral activity and application in antihelminthic research[1]. Niclosamide olamin is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Otherwise, Niclosamide olamin also shows effectiveness against cancer by inhibiting DNA replication in Vero E6 cells[2].[3].[5].
体内研究

Niclosamide sodium, when given via oral gavage at doses of 100 mg/kg and 200 mg/kg once a week for eight weeks, significantly reduces tumor growth in adrenocortical carcinoma models in vivo[3].
体外研究

Niclosamide olamine, across a range of concentrations from 0.6 nM to 46 µM, effectively inhibits cellular proliferation in adrenocortical carcinoma lines including BD140A, SW-13, and NCI-H295R cells[3].

Additionally, when administered at concentrations of 0.05 to 5 µM for 24 hours, Niclosamide olamine suppresses STAT3-mediated luciferase reporter activity in HeLa cells[4].

Niclosamide olamine also inhibits virus replication at a concentration of 10 µM in Vero E6 cells[5].

Niclosamide Ethanolamine Salt 参考文献

[1]P Andrews, et al. The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther. 1982;19(2):245-95.

[2]Wei Chen, et al. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89-96.

[3]Kei Satoh, et al. Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma. Clin Cancer Res. 2016 Jul 15;22(14):3458-66.

[4]Xiaomei Ren, et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9.

[5]Chang-Jer Wu, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48(7):2693-6.

Niclosamide Ethanolamine Salt 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.58mL

0.52mL

0.26mL

12.88mL

2.58mL

1.29mL

25.76mL

5.15mL

2.58mL

Niclosamide Ethanolamine Salt 技术信息

CAS号1420-04-8
分子式C15H15Cl2N3O5
分子量 388.203
别名 Niclosamide olamine;BAY2353 olamine;Niclosamide-olamine, Niclosamide (ethanolamine salt);HL 2448;Bayluscide;BAY-6076;BAY-73;Niclosamide (ethanolamine salt)
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,2-8°C
溶解度

DMSO: 120 mg/mL(309.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Niclosamide | 1420-04-8 | BAY2353 | BAY 2353 | BAY-2353 | JAK/STAT Signaling | Stem Cell/Wnt | Anti-infection | STAT | Parasite | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Niclosamide Ethanolamine Salt 纯度/质量文件 | Niclosamide Ethanolamine Salt 亚型比较 | Niclosamide Ethanolamine Salt 生物活性 | Niclosamide Ethanolamine Salt 参考文献 | Niclosamide Ethanolamine Salt 实验方案 | Niclosamide Ethanolamine Salt 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z