Niclosamide Ethanolamine Salt

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Chemical Structure| 1420-04-8 同义名 : Niclosamide olamine;BAY2353 olamine;Niclosamide-olamine, Niclosamide (ethanolamine salt);HL 2448;Bayluscide;BAY-6076;BAY-73;Niclosamide (ethanolamine salt)
CAS号 : 1420-04-8
货号 : A116636
分子式 : C15H15Cl2N3O5
纯度 : 98%
分子量 : 388.203
MDL号 : MFCD01941566
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(309.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Niclosamide olamine, another form of the drug, retains the same oral activity and application in antihelminthic research[1]. Niclosamide olamin is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Otherwise, Niclosamide olamin also shows effectiveness against cancer by inhibiting DNA replication in Vero E6 cells[2].[3].[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.58mL

0.52mL

0.26mL

12.88mL

2.58mL

1.29mL

25.76mL

5.15mL

2.58mL
参考文献

[1]P Andrews, et al. The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther. 1982;19(2):245-95.

[2]Wei Chen, et al. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89-96.

[3]Kei Satoh, et al. Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma. Clin Cancer Res. 2016 Jul 15;22(14):3458-66.

[4]Xiaomei Ren, et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9.

[5]Chang-Jer Wu, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48(7):2693-6.