There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
ZCL278 is a potent, cell-permeable inhibitor specific to Cdc42, suppressing actin-based cellular functions such as Golgi organization and cell motility. In Swiss 3T3 fibroblast cultures, ZCL278 disrupts microspike formation and GM130-docked Golgi structures, prominent Cdc42-mediated subcellular events. It reduces perinuclear accumulation of active Cdc42 compared to NSC23766, a selective Rac inhibitor. ZCL278 also inhibits Cdc42-mediated neuronal branching, growth cone dynamics, actin-based motility, and migration in PC-3 metastatic prostate cancer cells without impacting cell viability [1]. ZCL278 acts as an entry inhibitor for Junin virus (JUNV), vesicular stomatitis virus, lymphocytic choriomeningitis virus, and dengue virus, but not for nonenveloped poliovirus. It efficiently inhibits chemically induced filopodium formation, a process dependent on Cdc42 activity. Dose-response experiments in Vero cells show that ZCL278, up to 200 μM, is not toxic but inhibits JUNV with an IC50 of ~14 μM, measured by flow cytometry [2].
体内研究
ZCL278 decreases JUNV RNA load in the spleen over 33-fold, with JUNV RNA undetectable in 5 out of 8 mice, similar to Gabapentin-treated mice, indicating ZCL278's ability to halt JUNV replication [2].
体外研究
ZCL278 is a potent, cell-permeable inhibitor specific to Cdc42, suppressing actin-based cellular functions such as Golgi organization and cell motility. In Swiss 3T3 fibroblast cultures, ZCL278 disrupts microspike formation and GM130-docked Golgi structures, prominent Cdc42-mediated subcellular events. It reduces perinuclear accumulation of active Cdc42 compared to NSC23766, a selective Rac inhibitor. ZCL278 also inhibits Cdc42-mediated neuronal branching, growth cone dynamics, actin-based motility, and migration in PC-3 metastatic prostate cancer cells without impacting cell viability [1].
ZCL278 acts as an entry inhibitor for Junin virus (JUNV), vesicular stomatitis virus, lymphocytic choriomeningitis virus, and dengue virus, but not for nonenveloped poliovirus. It efficiently inhibits chemically induced filopodium formation, a process dependent on Cdc42 activity. Dose-response experiments in Vero cells show that ZCL278, up to 200 μM, is not toxic but inhibits JUNV with an IC50 of ~14 μM, measured by flow cytometry [2].
作用机制
ZCL278 is a small molecule that binds to Cdc42 residues to target the interaction between Cdc42 and intersectin and inhibits Cdc42-mediated cellular processes.
搜索
HazMat Fee +
