NSC 23766 3HCl | NSC 23766 (hydrochloride) | Ra Inhibitor

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NSC 23766 3HCl {[allProObj[0].p_purity_real_show]}

货号：A252594 同义名： NSC 23766 (hydrochloride);NSC 23766

NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification.

NSC 23766 3HCl 化学结构
CAS号：1177865-17-6

NSC 23766 3HCl 3D分子结构
CAS号：1177865-17-6

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NSC 23766 3HCl 纯度/质量文件产品仅供科研

货号：A252594 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

NSC 23766 3HCl 生物活性

靶点	Rac Rac GTPase, IC50:50 μM

NSC 23766 3HCl 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
A172MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
A172MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120
A431	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
A431	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327

NSC 23766 3HCl 参考文献

[1]54:50-56.

[2]6:34415. Published 2016 Oct 3.

[3]Payapilly A, Malliri A. Compartmentalisation of RAC1 signalling. Curr Opin Cell Biol. 2018;54:50-56.

NSC 23766 3HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.88mL

0.38mL

0.19mL

9.42mL

1.88mL

0.94mL

18.83mL

3.77mL

1.88mL

NSC 23766 3HCl 技术信息

CAS号	1177865-17-6
分子式	C₂₄H₃₈Cl₃N₇
分子量	530.964

别名	NSC 23766 (hydrochloride);NSC 23766;NSC 23766 trihydrochloride
运输	蓝冰

存储条件

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 35 mg/mL(65.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 30 mg/mL(56.5 mM)

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

A172MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
A172MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120
A431	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
A431	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327
IEC-6	120 µM	Function Assay	4/6/8 h	prevents the increased activation of FAK at 6 and 8 h	20448461
Ki-67+ CLL	50 µM	Growth Inhibition Assay	5 d	decreases the number of Ki-67+ CLL cells	24501217
MCF7	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
MCF7	100 μM	Function Assay	48 h	increases the cell number in G1 phase and decreases the cell number in S and G2-M phases	20515940
MDA-MB-231	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
MDA-MB-231	0-100 μM	Function Assay	24 h	selectively inhibits Rac1 activation without interfering with the activity of the closely related small GTPase Cdc42	20515940
MDA-MB-231	100 μM	Function Assay	48 h	increases the cell number in G1 phase and decreases the cell number in S and G2-M phases	20515940
MDA-MB-231	50/100 μM	Function Assay	24 h	increases phosphorylation of JNK in a dose dependent manner	20515940
MDA-MB-231	50/100 μM	Function Assay	48 h	induces a dose-dependent decrease in phosphorylation of p65 subunit	20515940
MDA-MB-468	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
MDA-MB-468	50/100 μM	Apoptosis Assay	24 h	induces apoptosis	20515940
MDA-MB-468	100 μM	Function Assay	24 h	inhibits caspase-3 activation	20515940
MDA-MB-468	50/100 μM	Function Assay	24 h	increases phosphorylation of JNK in a dose dependent manner	20515940
MDA-MB-468	50/100 μM	Function Assay	48 h	induces a dose-dependent decrease in phosphorylation of p65 subunit	20515940
NCI-H1703	0-500 μM	Growth Inhibition Assay	24 h	inhibits cell growth in a dose dependent manner	22549160
NCI-H1703	100 μg/ml	Function Assay	24 h	slows progression through the G1 phase of the cell cycle	22549160
NCI-H1703	0-500 μM	Function Assay	24 h	diminishes basal NF-κB activity dose dependently	22549160
NIH3T3	100 μM	Growth Inhibition Assay	24 h	has no significant impact on cell viability	25037060
PC38	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
PC40	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
RA1	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA2	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA3	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA4	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA-FLS (RA2)	25/50 μM	Growth Inhibition Assay	1-9 d	inhibits cell growth in both dose and time dependent manner	17622308
RBMECs	100 μM	Function Assay	30 min	blockes 6Bnz-cAMP-mediated activation of Rac1 in EMAP-II-treated RBMECs	26358039
SKBR3	50 μM	Function Assay	24 h	inhibits Rac1 activation	21943825
SKBR3-pMKO.1	50 μM	Function Assay	24 h	inhibits Rac1 activation	21943825
SW480	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
SW480	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327
T47D	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
T47D	100 μM	Function Assay	48 h	increases the cell number in G1 phase and decreases the cell number in S and G2-M phases	20515940
T98MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
T98MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120
U2-OS	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
U2-OS	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327
U87MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
U87MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120

NSC 23766 3HCl {[allProObj[0].p_purity_real_show]}

NSC 23766 3HCl 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

NSC 23766 3HCl 质控信息

NSC 23766 3HCl 生物活性

NSC 23766 3HCl 细胞研究

NSC 23766 3HCl 参考文献

NSC 23766 3HCl 实验方案

NSC 23766 3HCl 技术信息

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NSC 23766 3HCl {[allProObj[0].p_purity_real_show]}

NSC 23766 3HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

NSC 23766 3HCl 质控信息

NSC 23766 3HCl 生物活性

NSC 23766 3HCl 细胞研究

NSC 23766 3HCl 参考文献

NSC 23766 3HCl 实验方案

NSC 23766 3HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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