NSC 23766 3HCl | NSC 23766 (hydrochloride) | Ra Inhibitor

首页 / / / Ras / NSC 23766 3HCl

NSC 23766 3HCl {[allProObj[0].p_purity_real_show]}

货号：A252594 同义名： NSC 23766 (hydrochloride);NSC 23766

NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification.

NSC 23766 3HCl 化学结构
CAS号：1177865-17-6

NSC 23766 3HCl 3D分子结构
CAS号：1177865-17-6

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

NSC 23766 3HCl 纯度/质量文件产品仅供科研

货号：A252594 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

NSC 23766 3HCl 生物活性

靶点	Rac Rac GTPase, IC50:50 μM

NSC 23766 3HCl 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
A172MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
A172MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120
A431	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
A431	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327

NSC 23766 3HCl 参考文献

[1]54:50-56.

[2]6:34415. Published 2016 Oct 3.

[3]Payapilly A, Malliri A. Compartmentalisation of RAC1 signalling. Curr Opin Cell Biol. 2018;54:50-56.

NSC 23766 3HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.88mL

0.38mL

0.19mL

9.42mL

1.88mL

0.94mL

18.83mL

3.77mL

1.88mL

NSC 23766 3HCl 技术信息

CAS号	1177865-17-6
分子式	C₂₄H₃₈Cl₃N₇
分子量	530.964

别名	NSC 23766 (hydrochloride);NSC 23766;NSC 23766 trihydrochloride
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 35 mg/mL(65.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 30 mg/mL(56.5 mM)

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

A172MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
A172MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120
A431	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
A431	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327
IEC-6	120 µM	Function Assay	4/6/8 h	prevents the increased activation of FAK at 6 and 8 h	20448461
Ki-67+ CLL	50 µM	Growth Inhibition Assay	5 d	decreases the number of Ki-67+ CLL cells	24501217
MCF7	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
MCF7	100 μM	Function Assay	48 h	increases the cell number in G1 phase and decreases the cell number in S and G2-M phases	20515940
MDA-MB-231	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
MDA-MB-231	0-100 μM	Function Assay	24 h	selectively inhibits Rac1 activation without interfering with the activity of the closely related small GTPase Cdc42	20515940
MDA-MB-231	100 μM	Function Assay	48 h	increases the cell number in G1 phase and decreases the cell number in S and G2-M phases	20515940
MDA-MB-231	50/100 μM	Function Assay	24 h	increases phosphorylation of JNK in a dose dependent manner	20515940
MDA-MB-231	50/100 μM	Function Assay	48 h	induces a dose-dependent decrease in phosphorylation of p65 subunit	20515940
MDA-MB-468	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
MDA-MB-468	50/100 μM	Apoptosis Assay	24 h	induces apoptosis	20515940
MDA-MB-468	100 μM	Function Assay	24 h	inhibits caspase-3 activation	20515940
MDA-MB-468	50/100 μM	Function Assay	24 h	increases phosphorylation of JNK in a dose dependent manner	20515940
MDA-MB-468	50/100 μM	Function Assay	48 h	induces a dose-dependent decrease in phosphorylation of p65 subunit	20515940
NCI-H1703	0-500 μM	Growth Inhibition Assay	24 h	inhibits cell growth in a dose dependent manner	22549160
NCI-H1703	100 μg/ml	Function Assay	24 h	slows progression through the G1 phase of the cell cycle	22549160
NCI-H1703	0-500 μM	Function Assay	24 h	diminishes basal NF-κB activity dose dependently	22549160
NIH3T3	100 μM	Growth Inhibition Assay	24 h	has no significant impact on cell viability	25037060
PC38	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
PC40	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
RA1	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA2	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA3	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA4	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA-FLS (RA2)	25/50 μM	Growth Inhibition Assay	1-9 d	inhibits cell growth in both dose and time dependent manner	17622308
RBMECs	100 μM	Function Assay	30 min	blockes 6Bnz-cAMP-mediated activation of Rac1 in EMAP-II-treated RBMECs	26358039
SKBR3	50 μM	Function Assay	24 h	inhibits Rac1 activation	21943825
SKBR3-pMKO.1	50 μM	Function Assay	24 h	inhibits Rac1 activation	21943825
SW480	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
SW480	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327
T47D	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
T47D	100 μM	Function Assay	48 h	increases the cell number in G1 phase and decreases the cell number in S and G2-M phases	20515940
T98MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
T98MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120
U2-OS	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
U2-OS	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327
U87MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
U87MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120

NSC 23766 3HCl {[allProObj[0].p_purity_real_show]}

NSC 23766 3HCl 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

NSC 23766 3HCl 质控信息

NSC 23766 3HCl 生物活性

NSC 23766 3HCl 细胞研究

NSC 23766 3HCl 参考文献

NSC 23766 3HCl 实验方案

NSC 23766 3HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

NSC 23766 3HCl {[allProObj[0].p_purity_real_show]}

NSC 23766 3HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

NSC 23766 3HCl 质控信息

NSC 23766 3HCl 生物活性

NSC 23766 3HCl 细胞研究

NSC 23766 3HCl 参考文献

NSC 23766 3HCl 实验方案

NSC 23766 3HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

NSC 23766 3HCl 纯度/质量文件产品仅供科研