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Narciclasine

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Chemical Structure| 29477-83-6 同义名 : Lycoricidinol;(+)-Narciclasine;NSC 266535;Lycoricidin-A;Lycorcidinol;(+)-Lycoricidinol
CAS号 : 29477-83-6
货号 : A225129
分子式 : C14H13NO7
纯度 : 99%+
分子量 : 307.255
MDL号 : MFCD01729949
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(81.37 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Narciclasine triggers activation of Rho and stress fibers within glioblastoma multiforme (GBM) cells, exhibiting a mean IC50 of approximately 50 nM across six human GBM cell lines (U373, Hs683, GL19, GL5, GL16, GL17), which also demonstrates a mean IC50 value of 47 nM against a diverse array of 60 cancer cell lines[1]. Further exploration through bioassay-guided fractionation of A. belladonna extract pinpointed lycorine as the active compound, with Narciclasine showing a significant IC50 of 0.1 μM for radicle growth inhibition[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.25mL

0.65mL

0.33mL

16.27mL

3.25mL

1.63mL

32.55mL

6.51mL

3.25mL
参考文献

[1]Lefranc F, et al. Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol Cancer Ther. 2009 Jul;8(7):1739-50.

[2]Wahyuni DS, et al. The use of bio-guided fractionation to explore the use of leftover biomass in Dutch flower bulb production as allelochemicals against weeds. Molecules. 2013 Apr 17;18(4):4510-25.