莫诺苷 /Morroniside
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货号：A464826
同义名：
奎宁树
Morroniside is a naturally occuring iridoid which can regulate hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway.
Morroniside 化学结构
Morroniside 3D分子结构
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Morroniside 纯度/质量文件 产品仅供科研
货号：A464826
标准纯度：
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Morroniside 质控信息
Marimastat
+++
MMP-14, IC50: 3 nM
MMP-7, IC50: 16 nM
98%
Ilomastat
++++
MMP-2, Ki: 0.1 nM
MMP-26, Ki: 0.36 nM
99%+
SB-3CT
+
MMP-2, Ki: 13.9 nM
MMP-9, Ki: 600 nM
99%+
Doxycycline
✔
98%
NSC 405020
✔
98%
Batimastat
+++
MMP-1, IC50: 3 nM
MMP-7, IC50: 4 nM
99%+
Nobiletin
✔
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Morroniside 生物活性
描述
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression. Treatment with Morroniside significantly reduces I/R‑associated neuron apoptosis in a dose dependent manner[3] [4] [5] [6] [7]
Morroniside 参考文献
[1] Xiong S, Li J, et al. Induction of CYP3A by morroniside in rats. J Pharmacol Sci. 2015 Apr;127(4):414-8.
[2] Sun FL, Wang W, et al. Promoting neurogenesis via Wnt/β-catenin signaling pathway accounts for the neurorestorative effects of morroniside against cerebral ischemia injury. Eur J Pharmacol. 2014 Sep 5;738:214-21.
[3] Zeng G, Ding W, Li Y, Sun M, Deng L. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018 Sep;16(3):2229-2234
[4] Sun Y, Zhu Y, Liu X, Chai Y, Xu J. Morroniside attenuates high glucose-induced BMSC dysfunction by regulating the Glo1/AGE/RAGE axis. Cell Prolif. 2020 Aug;53(8):e12866
[5] Yu H, Yao S, Zhou C, Fu F, Luo H, Du W, Jin H, Tong P, Chen D, Wu C, Ruan H. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. J Ethnopharmacol. 2021 Feb 10;266:113447
[6] Park CH, Noh JS, Kim JH, Tanaka T, Zhao Q, Matsumoto K, Shibahara N, Yokozawa T. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34(10):1559-65
[7] Yu B, Zhang G, An Y, Wang W. Morroniside on anti-inflammation activities in rats following acute myocardial infarction. Korean J Physiol Pharmacol. 2018 Jan;22(1):17-21
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Morroniside 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.46mL
0.49mL
0.25mL
12.30mL
2.46mL
1.23mL
24.61mL
4.92mL
2.46mL
Morroniside 技术信息
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