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Morroniside

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Chemical Structure| 25406-64-8 同义名 : 奎宁树
CAS号 : 25406-64-8
货号 : A464826
分子式 : C17H26O11
纯度 : 99%+
分子量 : 406.382
MDL号 : MFCD00210532
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(258.38 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(123.04 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression. Treatment with Morroniside significantly reduces I/R‑associated neuron apoptosis in a dose dependent manner[3]. Morroniside treatment reverses the HG(High glucose)-impaired osteogenic differentiation of BMSCs in vitro. Furthermore, in vivo, morroniside attenuated bone loss and improved bone microarchitecture accompanied by Glo1 (glyoxalase-1) upregulation and RAGE (receptor for advanced glycation end product) downregulation[4]. Morroniside was protective against cartilage matrix degradation and reduced DMM(destabilization of the medial meniscus)-induced chondrocyte pyroptosis and apoptosis by the inhibition of NF-κB signaling[5]. The administration of morroniside (20 or 100 mg/kg body weight/d, per os (p.o.)) decreased the elevated serum glucose concentration in db/db mice, and reduced the increased oxidative biomarkers including the generation of ROS and lipid peroxidation in the liver[6]. Morroniside had effective anti-inflammatory properties in AMI (acute myocardial infarction) rats[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.46mL

0.49mL

0.25mL

12.30mL

2.46mL

1.23mL

24.61mL

4.92mL

2.46mL
参考文献

[1]Xiong S, Li J, et al. Induction of CYP3A by morroniside in rats. J Pharmacol Sci. 2015 Apr;127(4):414-8.

[2]Sun FL, Wang W, et al. Promoting neurogenesis via Wnt/β-catenin signaling pathway accounts for the neurorestorative effects of morroniside against cerebral ischemia injury. Eur J Pharmacol. 2014 Sep 5;738:214-21.

[3]Zeng G, Ding W, Li Y, Sun M, Deng L. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018 Sep;16(3):2229-2234

[4]Sun Y, Zhu Y, Liu X, Chai Y, Xu J. Morroniside attenuates high glucose-induced BMSC dysfunction by regulating the Glo1/AGE/RAGE axis. Cell Prolif. 2020 Aug;53(8):e12866

[5]Yu H, Yao S, Zhou C, Fu F, Luo H, Du W, Jin H, Tong P, Chen D, Wu C, Ruan H. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. J Ethnopharmacol. 2021 Feb 10;266:113447

[6]Park CH, Noh JS, Kim JH, Tanaka T, Zhao Q, Matsumoto K, Shibahara N, Yokozawa T. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34(10):1559-65

[7]Yu B, Zhang G, An Y, Wang W. Morroniside on anti-inflammation activities in rats following acute myocardial infarction. Korean J Physiol Pharmacol. 2018 Jan;22(1):17-21