Methyclothiazide | NSC 110431 | Antihypertensive Agent | AmBeed-信号通路专用抑制剂

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甲氯噻嗪 /Methyclothiazide

货号：A407281 同义名： NSC 110431

Methyclothiazide是一种取代苯并噻二氮杂类化合物，用于治疗高血压和由各种病症引起的体液潴留，包括心脏病。

Methyclothiazide 化学结构
CAS号：135-07-9

Methyclothiazide 3D分子结构
CAS号：135-07-9

规格	价格	库存
50μL*10mM(DMSO)	￥99随货￥69	咨询
100μL*10mM(DMSO)	￥139随货￥99	咨询
250μL*10mM(DMSO)	￥259随货￥189	咨询
500μL*10mM(DMSO)	￥369随货￥259	咨询
10mM*1mL(DMSO)	￥518	咨询
5mg	￥264	咨询
10mg	￥422	咨询
25mg	￥850	咨询
50mg	￥1449	咨询

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Methyclothiazide 纯度/质量文件产品仅供科研

货号：A407281 标准纯度：产品说明书

批次查询：批次纯度: COA NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • ACS Appl. Nano Mater., 2025. Ambeed. [ A188026 ]; • Eur. J. Clin. Microbiol. Infect. Dis., 2025. Ambeed. [ A151161 ]; • JJC, 2025, 20(Special Issue)): 27-39. Ambeed. [ A713856 ]; • bioRxiv, 2025. Ambeed. [ A538667 , A714873 , A126729 , A126049 , A446054 ]; • Nature Communications, 2025, 16, 1871. Ambeed. [ A508148 ]; 更多 >

碳酸酐酶亚型比较

产品名称	Carbonic Anhydrase ↓ ↑	Carbonic Anhydrase I ↓ ↑	Carbonic Anhydrase II ↓ ↑	Carbonic Anhydrase IV ↓ ↑	Carbonic Anhydrase IX ↓ ↑	Carbonic Anhydrase XII ↓ ↑	其他靶点	纯度
Topiramate	✔						Calcium Channel	98%
Dichlorphenamide	✔							98%
Mafenide Acetate	✔							98%
Benzenesulphonamide	✔							98%
Dorzolamide HCl		+ Carbonic anhydrase I, Ki: 6000 nM	++++ Carbonic anhydrase II, Ki: 1.9 nM	+++ Carbonic anhydrase IV, Ki: 31 nM				98%
Methazolamide		++ hCAI, Ki: 50 nM	+++ hCAII, Ki: 14 nM	++ bCAIV, Ki: 36 nM				98%
Tioxolone		+ CAI, Ki: 91 nM						98%
U-104					++ CAIX, Ki: 45.1 nM	++++ CAXII, Ki: 4.5 nM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Methyclothiazide 生物活性

描述	Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.

Methyclothiazide 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00208429	Rheumatoid Arthritis ... 展开 >> Osteoarthritis Post-traumatic Arthritis Collagen Disorders Avascular Necrosis Traumatic Femoral Fractures Nonunion of Femoral Fractures Congenital Hip Dysplasia Slipped Capital Femoral Epiphysis 收起 <<	Phase 4	Withdrawn(Site Principal Inves... 展开 >>tigator became seriously ill, so study abandoned before the start of recruitment) 收起 <<	July 1, 2019	-
NCT01121146	Osteoarthritis ... 展开 >> Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases 收起 <<	Not Applicable	Completed	-	United States, Virginia ... 展开 >> Anderson Orthopaedic Research Institute Alexandria, Virginia, United States, 22306 收起 <<
NCT00208442	Osteoarthritis ... 展开 >> Post-traumatic Arthritis Collagen Disorders Avascular Necrosis Traumatic Femoral Fractures Nonunion of Femoral Fractures Congenital Hip Dysplasia Slipped Capital Femoral Epiphysis 收起 <<	Phase 4	Completed	-	New Zealand ... 展开 >> University Otago, Wellington Medical School of Medicine Wellington, New Zealand 收起 <<

Methyclothiazide 参考文献

[1]Colas B, Slama M, et al. Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol. 2000 Nov 10;408(1):63-7.

[2]Colas B, Slama M, et al. Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rats. Fundam Clin Pharmacol. 2000 Jul-Aug;14(4):363-8.

Methyclothiazide 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.88mL

2.78mL

1.39mL

27.76mL

5.55mL

2.78mL

Methyclothiazide 技术信息

CAS号	135-07-9
分子式	C₉H₁₁Cl₂N₃O₄S₂
分子量	360.237

别名	NSC 110431
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,2-8°C

溶解方案

细胞实验：

DMSO: 75 mg/mL(208.2 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00208429	Rheumatoid Arthritis ... 展开 >> Osteoarthritis Post-traumatic Arthritis Collagen Disorders Avascular Necrosis Traumatic Femoral Fractures Nonunion of Femoral Fractures Congenital Hip Dysplasia Slipped Capital Femoral Epiphysis 收起 <<	Phase 4	Withdrawn(Site Principal Inves... 展开 >>tigator became seriously ill, so study abandoned before the start of recruitment) 收起 <<	July 1, 2019	-
NCT01121146	Osteoarthritis ... 展开 >> Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases 收起 <<	Not Applicable	Completed	-	United States, Virginia ... 展开 >> Anderson Orthopaedic Research Institute Alexandria, Virginia, United States, 22306 收起 <<
NCT00208442	Osteoarthritis ... 展开 >> Post-traumatic Arthritis Collagen Disorders Avascular Necrosis Traumatic Femoral Fractures Nonunion of Femoral Fractures Congenital Hip Dysplasia Slipped Capital Femoral Epiphysis 收起 <<	Phase 4	Completed	-	New Zealand ... 展开 >> University Otago, Wellington Medical School of Medicine Wellington, New Zealand 收起 <<
NCT01121146	-		Completed	-	-
NCT01484002	-		Enrolling by invitation	December 2017	United States, Massachusetts ... 展开 >> Orthopaedic Biomechanics and Biomaterials Laboratory at Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Virginia Anderson Orthopaedic Research Institute Alexandria, Virginia, United States, 22306 收起 <<
NCT02508428	Osteoarthritis ... 展开 >> Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases 收起 <<	Not Applicable	Enrolling by invitation	December 2030	United States, Virginia ... 展开 >> Anderson Orthopaedic Research Institute Alexandria, Virginia, United States, 22306 收起 <<

甲氯噻嗪 /Methyclothiazide

Methyclothiazide 纯度/质量文件产品仅供科研

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Methyclothiazide 生物活性

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Methyclothiazide 参考文献

Methyclothiazide 实验方案

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甲氯噻嗪 /Methyclothiazide

Methyclothiazide 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Methyclothiazide 质控信息

Methyclothiazide 生物活性

Methyclothiazide 临床研究

Methyclothiazide 参考文献

Methyclothiazide 实验方案

Methyclothiazide 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Methyclothiazide 纯度/质量文件产品仅供科研