噻克索酮 /Tioxolone
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货号：A436967
同义名：
Thioxolone
Tioxolone, a metalloenzyme carbonic anhydrase I
Tioxolone 化学结构
Tioxolone 3D分子结构
规格
价格
会员价
库存
数量
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现货
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-
+
Tioxolone 质控信息
Topiramate
✔
Calcium Channel
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Dichlorphenamide
✔
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Mafenide Acetate
✔
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Benzenesulphonamide
✔
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Dorzolamide HCl
+
Carbonic anhydrase I, Ki: 6000 nM
++++
Carbonic anhydrase II, Ki: 1.9 nM
+++
Carbonic anhydrase IV, Ki: 31 nM
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Methazolamide
++
+++
++
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Tioxolone
+
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U-104
++
++++
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Tioxolone 生物活性
靶点
Carbonic Anhydrase I
CAI, Ki:91 nM
描述
Thioxolone is proposed to be a prodrug inhibitor that is cleaved via a CA II zinc-hydroxide mechanism known to catalyze the hydrolysis of esters[3] [4] [5]
Tioxolone 参考文献
[1] Kim BH, Min YS, et al. Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling. Exp Mol Med. 2011 May 31;43(5):313-21.
[2] Byres M, Cox PJ. The supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one (tioxolone). Acta Crystallogr C. 2004 Jun;60(Pt 6):o395-6.
[3] Barrese AA 3rd, Genis C, Fisher SZ, Orwenyo JN, Kumara MT, Dutta SK, Phillips E, Kiddle JJ, Tu C, Silverman DN, Govindasamy L, Agbandje-McKenna M, McKenna R, Tripp BC. Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. Biochemistry. 2008 Mar 11;47(10):3174-84
[4] Sippel KH, Genis C, Govindasamy L, Agbandje-McKenna M, Kiddle JJ, Tripp BC, McKenna R. Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II. J Phys Chem Lett. 2010 Oct 7;1(19):2898-2902
[5] Innocenti A, Maresca A, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors? Bioorg Med Chem Lett. 2008 Jul 15;18(14):3938-41
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Tioxolone 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
5.95mL
1.19mL
0.59mL
29.73mL
5.95mL
2.97mL
59.46mL
11.89mL
5.95mL
Tioxolone 技术信息
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