Mafenide Acetate is a synthetic sulfonamide-derived with topical anti-infective activity, which acts through competition with PABA for the bacterial enzyme dihydropteroate synthase and thereby interfering with normal folic acid metabolism.
Mafenide acetate is an effective but costly antimicrobial solution used for burn wounds[3]. Hydrofiber saturated with mafenide acetate, whether stored on a dry well plate or nonsterile porcine skin, consistently possessed sustained antimicrobial activity as demonstrated by zones of inhibition greater than 2 mm to both S. aureus and P. aeruginosa[4]. In wounds treated with mafenide acetate, epithelialization occurred by day 7 in 72% of cases and in 84% by day 21. 52% of the mafenide acetate treated wounds showed reparative activity with inflammatory changes by day 7[5]. Mafenide acetate and amphotericin B did not seem to persistently meet the toxicity and efficacy balance as consistently as Dakin's solution[6].
United States, Kentucky
... 展开 >>
University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
United States, Kentucky
... 展开 >>
University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
United States, Florida
... 展开 >>
Shands at University of Florida
Gainesville, Florida, United States, 32610
United States, North Carolina
University of North Carolina, Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
United States, Tennessee
University of Tennessee Firefighter's Regional Burn Center
Memphis, Tennessee, United States, 38103 收起 <<
Terminated(FDA request as stud... 展开 >>y could not serve as the confirmatory trial as required under Subpart H approval.) 收起 <<
-
United States, Alabama
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University of South Alabama Medical Center
Mobile, Alabama, United States, 36617
United States, California
Arrowhead Regional Medical Center
Redlands, California, United States, 92373
United States, Florida
Shands Burn Center - Univ. of Florida
Gainesville, Florida, United States, 32610
United States, Illinois
Loyola University Medical Center
Maywood, Illinois, United States, 60153
The Plastic Surgery Institute - Southern Illinois Univ. School of Medicine
Springfield, Illinois, United States, 62794-9653
United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
United States, Maryland
John's Hopkins Burn Center
Baltimore, Maryland, United States, 21224
United States, Missouri
University of Missouri Healthcare - Dept. of Surgery
Columbia, Missouri, United States, 65212
United States, North Carolina
Wake Forest University - Department of General Surgery
Winston-Salem, North Carolina, United States, 27157 收起 <<
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