Dichlorphenamide is a sulfonamide and an orally bioavailablecarbonic anhydrase (CA) inhibitor with Kis of 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively.
Dichlorphenamide is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma. This drug has the same side-effects as acetazolamide, for which it is a useful substitute, except for a lesser tendency to cause dermatitis, renal calculi and metabolic acidosis. It may induce a more pronounced renal loss of potassium[3]. In two trials in patients with hypokalaemic periodic paralysis, dichlorphenamide was associated with a significantly (eightfold) lower paralytic attack rate and fewer patients with acute intolerable worsening compared with placebo. Dichlorphenamide is a valuable treatment option for patients with primary hyperkalaemic or hypokalaemic periodic paralysis[4]. Dichlorphenamide as well as Diamox lowers intraocular pressure. For adequate treatment of acute glaucoma only 20% of commonly used Diamoxdosis is requested to reach comparable pressure release two hours later. After one hour control intraocular pressure of 60% from patients with Dichlorphenamide treatment was found below 40 mm Hg since in Diamoxgroup there were only 30% below 40 mm Hg. Essential side effects after a single dosis of 200 mg Dichlorphenamide or in combination with Diamox for acute glaucoma treatment could not be observed[5].
United States, California
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UCLA Neurology
Los Angeles, California, United States, 90095
University of California-San Francisco
San Francisco, California, United States, 94143
United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
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Brigham & Women's Hospital
Boston, Massachusetts, United States, 02115
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Mayo Clinic
Rochester, Minnesota, United States, 55905
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Washington University School of Medicine
Saint Louis, Missouri, United States, 63110
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Columbia University Medical Center
New York, New York, United States, 10032
University of Rochester
Rochester, New York, United States, 14642
United States, Ohio
Ohio State University
Columbus, Ohio, United States, 43210
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University of Texas Southwestern-Dallas
Dallas, Texas, United States, 75390
Italy
University of Milan
San Donato, Milan, Italy
United Kingdom
Institute of Neurology-Queen's Square
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United States, California
... 展开 >>
UCLA Neurology
Los Angeles, California, United States, 90095
University of California-San Francisco
San Francisco, California, United States, 94143
United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
United States, Massachusetts
Brigham & Women's Hospital
Boston, Massachusetts, United States, 02115
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
United States, Missouri
Washington University School of Medicine
Saint Louis, Missouri, United States, 63110
United States, New York
Columbia University Medical Center
New York, New York, United States, 10032
University of Rochester
Rochester, New York, United States, 14642
United States, Ohio
Ohio State University
Columbus, Ohio, United States, 43210
United States, Texas
University of Texas Southwestern-Dallas
Dallas, Texas, United States, 75390
Italy
University of Milan
San Donato, Milan, Italy
United Kingdom
Institute of Neurology-Queen's Square
London, United Kingdom 收起 <<
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