产品说明书

Methyclothiazide

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Chemical Structure| 135-07-9 同义名 : NSC 110431
CAS号 : 135-07-9
货号 : A407281
分子式 : C9H11Cl2N3O4S2
纯度 : 98%
分子量 : 360.237
MDL号 : MFCD00242610
存储条件:

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 75 mg/mL(208.2 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00208429 Rheumatoid Arthritis ... 展开 >> Osteoarthritis Post-traumatic Arthritis Collagen Disorders Avascular Necrosis Traumatic Femoral Fractures Nonunion of Femoral Fractures Congenital Hip Dysplasia Slipped Capital Femoral Epiphysis 收起 << Phase 4 Withdrawn(Site Principal Inves... 展开 >>tigator became seriously ill, so study abandoned before the start of recruitment) 收起 << July 1, 2019 -
NCT01121146 Osteoarthritis ... 展开 >> Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases 收起 << Not Applicable Completed - United States, Virginia ... 展开 >> Anderson Orthopaedic Research Institute Alexandria, Virginia, United States, 22306 收起 <<
NCT00208442 Osteoarthritis ... 展开 >> Post-traumatic Arthritis Collagen Disorders Avascular Necrosis Traumatic Femoral Fractures Nonunion of Femoral Fractures Congenital Hip Dysplasia Slipped Capital Femoral Epiphysis 收起 << Phase 4 Completed - New Zealand ... 展开 >> University Otago, Wellington Medical School of Medicine Wellington, New Zealand 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.88mL

2.78mL

1.39mL

27.76mL

5.55mL

2.78mL

参考文献

[1]Colas B, Slama M, et al. Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol. 2000 Nov 10;408(1):63-7.

[2]Colas B, Slama M, et al. Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rats. Fundam Clin Pharmacol. 2000 Jul-Aug;14(4):363-8.