JQKD82 trihydrochloride
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货号：A1967108
同义名：
JADA82 trihydrochloride;PCK82 trihydrochloride
JQKD82 trihydrochloride 是一种细胞通透性和选择性 KDM5 抑制剂，能够增加 H3K4me3 水平，展现了在多发性骨髓瘤研究中的应用潜力，可用于表观遗传学的相关研究。
JQKD82 trihydrochloride 化学结构
JQKD82 trihydrochloride 3D分子结构
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+
JQKD82 trihydrochloride 质控信息
OG-L002
+++
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ORY-1001
+++
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SP-2509
++++
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GSK2879552 2HCl
+
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T-3775440 HCl
++++
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GSK-LSD1 2HCl
+++
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Pulrodemstat benzenesulfonate
✔
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IOX1
+
+++
++
KDM4E, IC50: 2.3 μM
KDM4C, IC50: 0.6 μM
+
+
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PFI-90
✔
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ML324
+
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NCGC00244536
++++
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KDM4D-IN-1
++
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GSK467
++++
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GSK-J1
+++
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(Z)-JIB-04
++
JMJD2E, IC50: 340 nM
JMJD2A, IC50: 1100 nM
++
++
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CPI-455
++++
++++
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JIB-04
++
JMJD2E, IC50: 435 nM
JMJD2D, IC50: 290 nM
++
++
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GSK-J4 HCl
+++
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
JQKD82 trihydrochloride 生物活性
描述
JQKD82 trihydrochloride, also known as JADA82, is a selective KDM5 inhibitor that permeates cells. It enhances H3K4me3 levels and is applicable in multiple myeloma research [1]
体内研究
JQKD82 trihydrochloride (50-75 mg/kg twice daily for 3 weeks) demonstrates anti-multiple myeloma activity [1]
JQKD82 trihydrochloride elevates H3K4me3 levels and significantly reduces MYC immunostaining in vivo [1]
体外研究
0.3 μM JQKD82 trihydrochloride for 24 hours induces a global increase in H3K4me3 levels in MM.1S cells [1]
JQKD82 trihydrochloride exhibits dose- and time-dependent growth inhibition with an IC50 of 0.42 μM in MM.1S cells, when administered at concentrations ranging from 0.1 to 10 μM over 5 days [1]
JQKD82 trihydrochloride (1 μM) induces G1 cell-cycle arrest within 48 hours in MM.1S and MOLP-8 cells [1]
JQKD82 trihydrochloride 参考文献
JQKD82 trihydrochloride 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.64mL
0.33mL
0.16mL
8.20mL
1.64mL
0.82mL
16.39mL
3.28mL
1.64mL
JQKD82 trihydrochloride 技术信息
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