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{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
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产品名称 | KDM1 ↓ ↑ | KDM2 ↓ ↑ | KDM3 ↓ ↑ | KDM4 ↓ ↑ | KDM5 ↓ ↑ | KDM6 ↓ ↑ | 其他靶点 | 纯度 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OG-L002 |
+++
LSD1, IC50: 20 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
ORY-1001 |
+++
LSD1, IC50: 20 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SP-2509 |
++++
LSD1, IC50: 13 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
GSK2879552 2HCl |
+
LSD1, Ki: 1.7 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
T-3775440 HCl |
++++
LSD1, IC50: 2.1 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
GSK-LSD1 2HCl |
+++
LSD1, IC50: 16 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Pulrodemstat benzenesulfonate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
IOX1 |
+
KDM2A, IC50: 1.8 μM |
+++
KDM3A, IC50: 0.1 μM |
++
KDM4E, IC50: 2.3 μM KDM4C, IC50: 0.6 μM |
+
KDM5C, IC50: 19 μM |
+
KDM6B, IC50: 1.6 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||
PFI-90 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
ML324 |
+
JMJD2, IC50: 920 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
NCGC00244536 |
++++
KDM4, IC50: 10 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
KDM4D-IN-1 |
++
KDM4D, IC50: 0.41 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
GSK467 |
++++
KDM5B, Ki: 10 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
GSK-J1 |
+++
JMJD3, IC50: 60 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
(Z)-JIB-04 |
++
JMJD2E, IC50: 340 nM JMJD2A, IC50: 1100 nM |
++
JARID1A, IC50: 230 nM |
++
JMJD3, IC50: 855 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
CPI-455 |
++++
KDM5A, IC50: 10 nM |
++++
KDM5, IC50: 10 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
JIB-04 |
++
JMJD2E, IC50: 435 nM JMJD2D, IC50: 290 nM |
++
JARID1A, IC50: 230 nM |
++
JMJD3, IC50: 855 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
GSK-J4 HCl |
+++
JMJD3, IC50: 60 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | JMJD5 and JMJD7 (JMJD5/7) are responsible for the clipping of arginine methylated histone tails to generate "tailless nucleosomes", which could release the pausing RNA polymerase II (Pol II) into productive transcription elongation. JMJD5/7 function as endopeptidases that cleave histone tails specifically adjacent to methylated arginine residues and continue to degrade N-terminal residues of histones via their aminopeptidase activity[2]. Knockouts of JMJD5 and JMJD7 dramatically increase the content of arginine-methylated histone tails as well as the overall content of histone subunits in cells. Deletion of JMJD7 genes in human breast cancer cells drastically reduces their growth in soft agar[3]. JMJD7 was present at gene promoters and its promoter occupancy changed upon osteoclast differentiation. Further, JMJD7 downregulation caused more rapid osteoclast differentiation[4]. The JMJD7-PLA2G4B fusion protein does not encompass the full JmjC domain of JMJD7-predicting absence of any enzymatic activity - but consists of nearly the whole PLA2G4B protein, the functions of JMJD7-PLA2G4B are likely to match those of PLA2G4B. In the same vein, the association of a sequence variant of the JMJD7-PLA2G4B gene with high-risk autism is unlikely due to dysregulated JMJD7 enzymatic activity[5]. JMJD7-IN-1 efficiently binds to JMJD7, with an IC50 of 3.80 μM. JMJD7-IN-1 (72 h) inhibits the growth of T-47d, SK-BR-3, Jurkat and Hela cells, with IC50s of 9.40 μM, 13.26 μM, 15.03 μM and 16.14 μM, respectively. JMJD7-IN-1 (0.1-1000 μM) dose-dependently inhibits the activity of JMJD7, with an IC50 of 6.62 μM[6]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.75mL 0.55mL 0.28mL |
13.77mL 2.75mL 1.38mL |
27.54mL 5.51mL 2.75mL |
CAS号 | 311316-96-8 |
分子式 | C16H8Cl2N2O4 |
分子量 | 363.152 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 7 mg/mL(19.28 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |