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IU1 {[allProObj[0].p_purity_real_show]}

货号:A875547

IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
IU1 化学结构 CAS号:314245-33-5
IU1 化学结构
CAS号:314245-33-5
IU1 3D分子结构
CAS号:314245-33-5
IU1 化学结构 CAS号:314245-33-5
IU1 3D分子结构 CAS号:314245-33-5
规格 价格 会员价 库存 数量
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IU1 纯度/质量文件 产品仅供科研

货号:A875547 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 DUB UCH USP/UBP 其他靶点 纯度
PR-619 +

Plpro, EC50: 14.2 μM

+++

UCH-L3, EC50: 2.95 μM

UCH-L5, EC50: 12.8 μM

+++

USP5, EC50: 4.90 μM

USP28, EC50: 6.24 μM

99%+
Degrasyn Bcr-Abl 98+%
VLX1570 +

DUB, IC50: ~10 μM

99%+
ML-323 ++++

USP1-UAF1, IC50: 76 nM

99%+
LDN-57444 ++++

UCH-L3, IC50: 25 μM

UCH-L1, IC50: 0.4 μM

99%+
TCID ++++

UCH-L3, IC50: 0.6 μM

98%
b-AP15 +++

UCHL5, IC50: 2.1 μM

98%
P 22077 ++

USP47, EC50: 8.74 μM

USP7, IC50: 8.6 μM

99%+
P005091 ++

USP47, IC50: 4.3 μM

USP7, EC50: 4.2 μM

99+%
IU1 ++

USP14, IC50: 4.7 μM

98%
NSC632839 +

USP2, EC50: 45 μM

USP7, EC50: 37 μM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 Autophagy 其他靶点 纯度
SBI-0206965 +++

ULK1, IC50: 108 nM

ULK2, IC50: 711 nM

97%
Hydroxychloroquine sulfate 99%
Valproic acid sodium HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

99%+
MRT68921 hydrochloride ++++

ULK1, IC50: 2.9 nM

ULK2, IC50: 1.1 nM

99%+
ROC-325 99%+
Autophinib +++

Autophagy, IC50: 40 nM

97%
Lys05 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

IU1 生物活性

靶点
  • USP/UBP

    USP14, IC50:4.7 μM

描述 Usp14, a proteasome-associated deubiquitinating enzyme, can impede the degradation of ubiquitin-protein conjugates, both in vivo and in vitro. IU1 inhibits the catalytic activity of proteasome-associated Usp14 in vitro, with an IC50 of 4-5 μM. IU1 specifically binds to the activated form of Usp14 and may inhibit it by preventing its docking on the proteasome. However, direct tests of this scenario yielded negative results. Usp14 inhibition is rapidly established upon IU1 addition and rapidly reversed upon its removal. IU1 also promotes the degradation of Sic1, a CDK inhibitor from S. cerevisiae [1].
体外研究

Usp14, a proteasome-associated deubiquitinating enzyme, can impede the degradation of ubiquitin-protein conjugates, both in vivo and in vitro. IU1 inhibits the catalytic activity of proteasome-associated Usp14 in vitro, with an IC50 of 4-5 μM. IU1 specifically binds to the activated form of Usp14 and may inhibit it by preventing its docking on the proteasome. However, direct tests of this scenario yielded negative results. Usp14 inhibition is rapidly established upon IU1 addition and rapidly reversed upon its removal. IU1 also promotes the degradation of Sic1, a CDK inhibitor from S. cerevisiae [1].

IU1 参考文献

[1]Lee BH, et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 2010 Sep 9;467(7312):179-84.

IU1 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.65mL

3.33mL

1.66mL

33.29mL

6.66mL

3.33mL

IU1 技术信息

CAS号314245-33-5
分子式C18H21FN2O
分子量 300.371
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 40 mg/mL(133.17 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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