NSC632839
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货号：A457204
同义名：
Ubiquitin Isopeptidase Inhibitor II;F6
NSC 632839 HCl is an nonselective inhibitor of isopeptidase and inhibits various proteins including USP2, USP7, and SENP2 (EC50 = 45 ± 4 μM, 37 ± 1 μM, and 9.8 ± 1.8 μM, respectively).
NSC632839 化学结构
NSC632839 3D分子结构
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NSC632839 纯度/质量文件 产品仅供科研
货号：A457204
标准纯度：
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产品说明书
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NSC632839 质控信息
PR-619
+
+++
UCH-L3, EC50: 2.95 μM
UCH-L5, EC50: 12.8 μM
+++
USP28, EC50: 6.24 μM
USP5, EC50: 4.90 μM
99%+
Degrasyn
✔
Bcr-Abl
98+%
VLX1570
+
99%+
ML-323
++++
99%+
LDN-57444
++++
UCH-L1, IC50: 0.4 μM
UCH-L3, IC50: 25 μM
99%+
TCID
++++
98%
b-AP15
+++
98%
P 22077
++
USP47, EC50: 8.74 μM
USP7, IC50: 8.6 μM
99%+
P005091
++
USP7, EC50: 4.2 μM
USP47, IC50: 4.3 μM
99+%
IU1
++
98%
NSC632839
+
USP7, EC50: 37 μM
USP2, EC50: 45 μM
99%+
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
NSC632839 生物活性
靶点
USP/UBP
USP7, EC50:37 μM
USP2, EC50:45 μM
描述
Deubiquitylases (DUBs), isopeptidases that cleave at the carboxyl terminus of ubiquitin, have been divided into five distinct groups, the largest being the ubiquitin-specific proteases (USP/UBP). NSC 632839 is an inhibitor of DUB with IC50 values of 45 nM, 37 nM and 9.8 nM for USP2, USP7, and SENP2, respectively[3] [4] [5]
NSC632839 参考文献
[1] Aleo E, Henderson CJ, et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 2006 Sep 15;66(18):9235-44.
[2] Nicholson B, Leach CA, et al. Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci. 2008 Jun;17(6):1035-43.
[3] Nicholson B, Leach CA, Goldenberg SJ, Francis DM, Kodrasov MP, Tian X, Shanks J, Sterner DE, Bernal A, Mattern MR, Wilkinson KD, Butt TR. Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci. 2008 Jun;17(6):1035-43.
[4] Aleo E, Henderson CJ, Fontanini A, Solazzo B, Brancolini C. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 2006 Sep 15;66(18):9235-44.
[5] Yan C, Huo H, Yang C, Zhang T, Chu Y, Liu Y. Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity. Biochem Biophys Res Commun. 2018 Mar 4;497(2):726-733.
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NSC632839 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.94mL
0.59mL
0.29mL
14.71mL
2.94mL
1.47mL
29.42mL
5.88mL
2.94mL
NSC632839 技术信息
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