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福沙那伟钙 /Fosamprenavir Calcium Salt {[allProObj[0].p_purity_real_show]}

货号:A484468 同义名: Fosamprenavir calcium;GW433908G

Fosamprenavir Calcium the prodrug of amprenavir which is an HIV protease inhibitor with antiviral property.

Fosamprenavir Calcium Salt 化学结构 CAS号:226700-81-8
Fosamprenavir Calcium Salt 化学结构
CAS号:226700-81-8
Fosamprenavir Calcium Salt 3D分子结构
CAS号:226700-81-8
Fosamprenavir Calcium Salt 化学结构 CAS号:226700-81-8
Fosamprenavir Calcium Salt 3D分子结构 CAS号:226700-81-8
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Fosamprenavir Calcium Salt 纯度/质量文件 产品仅供科研

货号:A484468 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 HIV Protease HIV-1 caspid 其他靶点 纯度
Dextran sulfate sodium, mw 40,000 M.W 40000
Vicriviroc maleate 98+%
Rosamultin 97%
Darunavir 98%
Lopinavir ++++

HIV protease, Ki: 1.3 pM

99+%
Chloroquine Autophagy 95%
Amprenavir +

HIV protease, IC50: 14.6 ng/mL

PXR 99%+
NBD-556 99%+
Nelfinavir Mesylate +++

HIV protease, Ki: 2 nM

99%+
Atazanavir Sulfate 98%
Limonin 98%
Saquinavir ++

HIV proteinase, IC50: 2.7 nM

98%
Ritonavir 98%
Azvudine 98%
Lenacapavir ++++

HIV-1 capsid, EC50: 0.1 nM

97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Fosamprenavir Calcium Salt 生物活性

描述 Newly released human immunodeficiency virus type 1 (HIV-1) particles obligatorily undergo a maturation process to become infectious. The HIV-1 protease initiates this step, catalyzing the cleavage of the Gag and Gag-Pro-Pol structural polyproteins[3]. Fosamprenavir, the phosphate ester prodrug of the HIV-1 PI (protease inhibitor) amprenavir, is one of the most recently approved HIV-1 PIs. The availability of fosamprenavir allows for substantial reductions in pill number and pill size, and omits the need for food and fluid requirements that are associated with some of the other HIV-1 Pis. Three fosamprenavir dosage regimens are approved for the treatment of HIV-1 PI-naive patients, including fosamprenavir 1,400 mg twice daily, fosamprenavir 1,400 mg once daily plus ritonavir 200 mg once daily, and fosamprenavir 700 mg twice daily plus ritonavir 100 mg twice daily. Plasma amprenavir concentrations are quantifiable within 15 minutes of dosing and peak at 1.5-2 hours after fosamprenavir dosing[4]. Fosamprenavir has been compared with amprenavir in a 6-week randomised controlled trial in HIV-infected adults. Amprenavir 1200 mg twice daily was compared with fosamprenavir 1395 mg twice daily or 1860 mg twice daily. Peak plasma amprenavir concentrations were 30% lower with fosamprenavir, AUCs were equivalent, and trough concentrations were increased by 28% with fosamprenavir 1395 mg twice daily and 46% with fosamprenavir 1860 mg twice daily[5].

Fosamprenavir Calcium Salt 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03290131 Multiple Sclerosis ... 展开 >> Spasticity, Muscle 收起 << Phase 3 Recruiting April 2019 United States, Arizona ... 展开 >> Xenoscience Inc. Recruiting Phoenix, Arizona, United States, 85004 United States, California Neuro-Pain Medical Center Recruiting Fresno, California, United States, 93710 United States, Florida Meridien Research Recruiting Tampa, Florida, United States, 33634 收起 <<
NCT03222349 Epilepsy Phase 2 Recruiting November 24, 2018 United States, Arizona ... 展开 >> University of Arizona Recruiting Tucson, Arizona, United States, 85719 Contact: Sejal Jain          United States, Florida NW FL Clinical Research Group, LLC Recruiting Gulf Breeze, Florida, United States, 32561 Contact: Weldon Mauney          United States, New Jersey Children's St. Peters University Hospital Recruiting New Brunswick, New Jersey, United States, 08901 Contact: Carlos Lastra          United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Harriet Kang, MD    914-428-0529       Principal Investigator: Harriet Kang, MD          Sub-Investigator: Patricia McGoldrick, NP          Sub-Investigator: Steven Wolf, MD          University of Rochester Recruiting Rochester, New York, United States, 14607 Contact: Inna Hughes          United States, North Carolina Onsite Clinical Solutions LLC Recruiting Charlotte, North Carolina, United States, 28203 Contact: Robert Nahouraii          United States, Pennsylvania Children's Hospital of Philadelphia Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Dennis Dlugos          United States, Texas Dell Children's Medical Center Recruiting Austin, Texas, United States, 78723 Contact: David Clarke          Austin Epilepsy Care Center Recruiting Austin, Texas, United States, 78758 Contact: Sami Aboumatar, MD    512-339-8831    sami@northaustinneuro.com    United States, Virginia Virginia Commonwealth University Recruiting Richmond, Virginia, United States, 23298 Contact: Syndi Seinfeld 收起 <<
NCT03179891 Epilepsy Phase 2 Recruiting April 29, 2019 United States, Arizona ... 展开 >> Arizona Health Sciences Center Recruiting Tucson, Arizona, United States, 85724-5023 Contact: David M. Labiner, MD    520-626-2006       United States, California Rancho Research Institute Recruiting Downey, California, United States, 90242 Contact: Hui Gong, MD    818-822-4916    hgong2@dhs.lacounty.gov    United States, Connecticut Yale University School of Medicine-Comprehensive Epilepsy Center Recruiting New Haven, Connecticut, United States, 06520-8018 Contact: Kamil Detyniecki, MD    203-785-3865    kamil.detyniecki@yale.edu    United States, Hawaii Hawaii Pacific Neuroscience Recruiting Honolulu, Hawaii, United States, 96817 Contact: Kore Liow, MD    808-261-4476    kliow@hawaiineuroscience.com    United States, Maryland Mid-Atlantic Epilepsy and Sleep Center Recruiting Bethesda, Maryland, United States, 20817 Contact: Pavel Klein, M.B.    301-530-9744    kleinp@epilepsydc.com    Contact: Diep Bui, M.D.          United States, New Jersey Saint Peter's University Hospital Recruiting New Brunswick, New Jersey, United States, 08901 Contact: Carlos Lastra, MD    732-745-8600    clastra@saintpetersuh.com    United States, New York University of Rochester Medical Center Recruiting Rochester, New York, United States, 14642 Contact: Trenton J. Tollefson, MD    507-273-4872    trenton_tollefson@urmc.rochester.edu    United States, North Carolina Onsite Clinical Solutions LLC Recruiting Charlotte, North Carolina, United States, 28203 Contact: Robert Ataollah Nahouraii          United States, Pennsylvania Hospital of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Michael A. Gelfand, MD, PhD    215-349-5166    michael.gelfand@uphs.upenn.edu    United States, Texas Austin Epilepsy Care Center Recruiting Austin, Texas, United States, 78758 Contact: Sami Aboumatar, MD    512-339-8831    sami@northaustinneuro.com    United States, Virginia Virginia Commonwealth University Medical Center Recruiting Richmond, Virginia, United States, 23219 Contact: Syndi A. Seinsefl, DO    804-828-0445    syndi.seinfeld@vcuhealth.org 收起 <<

Fosamprenavir Calcium Salt 参考文献

[1]Gruber VA, Rainey PM, et al. Interactions between buprenorphine and the protease inhibitors darunavir-ritonavir and fosamprenavir-ritonavir. Clin Infect Dis. 2012 Feb 1;54(3):414-23.

[2]Falcoz C, Jenkins JM, et al. Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98.

[3]The Triple Threat of HIV-1 Protease Inhibitors

[4]Fosamprenavir : Clinical Pharmacokinetics and Drug Interactions of the Amprenavir Prodrug

[5]Amprenavir or Fosamprenavir Plus Ritonavir in HIV Infection: Pharmacology, Efficacy and Tolerability Profile

Fosamprenavir Calcium Salt 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.02mL

1.60mL

0.80mL

16.03mL

3.21mL

1.60mL

Fosamprenavir Calcium Salt 技术信息

CAS号226700-81-8
分子式C25H34CaN3O9PS
分子量 623.669
别名 Fosamprenavir calcium;GW433908G;Fosamprenavir (calcium salt)
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 50 mg/mL(80.17 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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