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首页 / 抑制剂/激动剂 / 膜转运蛋白 / 质子泵 / Esomeprazole magnesium trihydrate

埃索美拉唑镁三水合物 /Esomeprazole magnesium trihydrate {[allProObj[0].p_purity_real_show]}

货号：A157451 同义名： 三水埃索美拉唑镁 / (S)-Omeprazole magnesium trihydrate;(-)-Omeprazole magnesium trihydrate

Esomeprazole Magnesium Trihydrate can inhibit the H+/K+ ATPase and reduce acid secretion of gastric parietal cells.

Esomeprazole magnesium trihydrate 化学结构 CAS号：217087-09-7
Esomeprazole magnesium trihydrate 化学结构
CAS号：217087-09-7
Esomeprazole magnesium trihydrate 3D分子结构
CAS号：217087-09-7
Esomeprazole magnesium trihydrate 化学结构 CAS号：217087-09-7
Esomeprazole magnesium trihydrate 3D分子结构 CAS号：217087-09-7
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Esomeprazole magnesium trihydrate 纯度/质量文件 产品仅供科研

货号：A157451 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Proton Pump ↓ 其他靶点 纯度
Zinc pyrithione ✔ 98+%
PF 03716556 ++++

H+/K+-ATPase, pIC50: ~6.5

 		98%
Lansoprazole ✔ 98%
Esomeprazole Magnesium ✔ 98%+
Rabeprazole ✔ 99%+
Ilaprazole ✔ TOPK 97%
Bafilomycin A1 ++++

H+-ATPase, IC50: 0.44 nM

 		95%
Pantoprazole sodium ✔ 98%
(R)-Lansoprazole ✔ 98%
Tenatoprazole ✔ 99%+
Omeprazole ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Esomeprazole magnesium trihydrate 生物活性

描述 Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate demonstrates promise in the research of upper intestinal disorders and gastroesophageal reflux disease[1].[2]. Through the suppression of V-H+-ATPases, Esomeprazole magnesium trihydrate functions as an inhibitor of exosomes, preventing their release[4].
体内研究

Treatment with Esomeprazole magnesium (0.5-50 mg/kg; orally via gavage; daily; over 10 days; in A/J mice) leads to an enhancement in gastric total antioxidant capacity and the activity of Cu/Zn-superoxide dismutase[1].
体外研究

Esomeprazole magnesium trihydrate was developed from Esomeprazole strontium tetrahydrate (EST), which includes esomeprazole, the S-enantiomer of omeprazole, and represents a salt-exchanged form of Esomeprazole magnesium trihydrate[2].

Esomeprazole magnesium trihydrate 参考文献

[1]Timothy R Koch, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep;15(9):522-6.

[2]Pankaj Kumar, et al. Preparation and characterization of pH-sensitive methyl methacrylate-g-starch/hydroxypropylated starch hydrogels: in vitro and in vivo study on release of esomeprazole magnesium. Drug Deliv Transl Res. 2015 Jun;5(3):243-56.

[3]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.

Esomeprazole magnesium trihydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.30mL

0.26mL

0.13mL

6.52mL

1.30mL

0.65mL

13.03mL

2.61mL

1.30mL

Esomeprazole magnesium trihydrate 技术信息

CAS号217087-09-7
分子式C34H42MgN6O9S2
分子量 767.167
别名 三水埃索美拉唑镁 ;(S)-Omeprazole magnesium trihydrate;(-)-Omeprazole magnesium trihydrate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 50 mg/mL(65.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Esomeprazole magnesium | 217087-09-7 | (S)-Omeprazole magnesium | (-)-Omeprazole magnesium | H+, K+-ATPase Inhibitor | Membrane Transporter/Ion Channel | Proton Pump | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Esomeprazole magnesium trihydrate 纯度/质量文件 | Esomeprazole magnesium trihydrate 亚型比较 | Esomeprazole magnesium trihydrate 生物活性 | Esomeprazole magnesium trihydrate 参考文献 | Esomeprazole magnesium trihydrate 实验方案 | Esomeprazole magnesium trihydrate 技术信息

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