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Esomeprazole magnesium trihydrate

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Chemical Structure| 217087-09-7 同义名 : 三水埃索美拉唑镁 ;(S)-Omeprazole magnesium trihydrate;(-)-Omeprazole magnesium trihydrate
CAS号 : 217087-09-7
货号 : A157451
分子式 : C34H42MgN6O9S2
纯度 : 98%
分子量 : 767.167
MDL号 : MFCD07698573
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(65.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate demonstrates promise in the research of upper intestinal disorders and gastroesophageal reflux disease[1].[2]. Through the suppression of V-H+-ATPases, Esomeprazole magnesium trihydrate functions as an inhibitor of exosomes, preventing their release[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.30mL

0.26mL

0.13mL

6.52mL

1.30mL

0.65mL

13.03mL

2.61mL

1.30mL
参考文献

[1]Timothy R Koch, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep;15(9):522-6.

[2]Pankaj Kumar, et al. Preparation and characterization of pH-sensitive methyl methacrylate-g-starch/hydroxypropylated starch hydrogels: in vitro and in vivo study on release of esomeprazole magnesium. Drug Deliv Transl Res. 2015 Jun;5(3):243-56.

[3]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.