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圣草次苷 /Eriocitrin {[allProObj[0].p_purity_real_show]}

货号：A205759 同义名： 圣草次甙 / Eriodictioside;eriodictyol 7-rutinoside

Eriocitrin is a natural product isolated and purified from the fruits of Citrus sinensis (L.) Osbeck with antioxidative activity.

Eriocitrin 化学结构 CAS号：13463-28-0
Eriocitrin 化学结构
CAS号：13463-28-0
Eriocitrin 3D分子结构
CAS号：13463-28-0
Eriocitrin 化学结构 CAS号：13463-28-0
Eriocitrin 3D分子结构 CAS号：13463-28-0
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Eriocitrin 纯度/质量文件 产品仅供科研

货号：A205759 标准纯度： {[allProObj[0].p_purity_real_show]}
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Eriocitrin 生物活性

描述 Eriocitrin is a flavonoid isolated from lemon, which is a strong antioxidant agent. Eriocitrin could inhibit the proliferation of hepatocellular carcinoma cell lines by arresting cell cycle in S phase through up-regulation of p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating mitochondria-involved intrinsic signaling pathway[3]. Eriocitrin attenuated oxidative injury and inflammatory response in rats with CI/R (cerebral ischemia reperfusion) via the Nrf2/HO-1/NQO1/NF-κB signaling pathway[4]. Oral administration of eriocitrin (32 mg/kg/day for 28 days) improved dyslipidaemia and decreased lipid droplets in the liver. In HepG2 cells, eriocitrin also induced the corresponding orthologues, and reduced lipid accumulation under conditions of lipid loading[5]. The 25 mg dose of eriocitrin had positive effects on oxidative stress, systemic inflammation and metabolism of lipids and glucose in general[6].

Eriocitrin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02627547 Healthy Not Applicable Completed - United Kingdom ... 展开 >> University of Glasgow School of Medicine Glasgow, United Kingdom 收起 <<
NCT03482401 Breast Cancer Not Applicable Active, not recruiting June 1, 2019 Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 <<
NCT03215043 Pre Diabetes Not Applicable Recruiting June 28, 2019 Brazil ... 展开 >> Sao Paulo State University "Julio de Mesquita Filho", Faculdade de Ciências Farmacêuticas Recruiting Araraquara, Sao Paulo, Brazil, 14800-903 Contact: Thais B Cesar, Ph.D.    +55 16 3301-6927    tcesar@fcfar.unesp.br 收起 <<

Eriocitrin 参考文献

[1]Hiramitsu M, Shimada Y, et al. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014 Jan 15;4:3708.

[2]Minato K, Miyake Y, et al. Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver. Life Sci. 2003 Feb 21;72(14):1609-16.

[3]Wang Z, Zhang H, Zhou J, Zhang X, Chen L, Chen K, Huang Z. Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle. Cancer Chemother Pharmacol. 2016 Dec;78(6):1143-1150

[4]He J, Zhou D, Yan B. Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2/NQO-1/HO-1/NF-κB p65 proteins. Ann Transl Med. 2020 Jun;8(12):757

[5]Hiramitsu M, Shimada Y, Kuroyanagi J, Inoue T, Katagiri T, Zang L, Nishimura Y, Nishimura N, Tanaka T. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014 Jan 15;4:3708

[6]Ferreira PS, Manthey JA, Nery MS, Spolidorio LC, Cesar TB. Low doses of eriocitrin attenuate metabolic impairment of glucose and lipids in ongoing obesogenic diet in mice. J Nutr Sci. 2020 Dec 14;9:e59

Eriocitrin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.38mL

1.68mL

0.84mL

16.76mL

3.35mL

1.68mL

Eriocitrin 技术信息

CAS号13463-28-0
分子式C27H32O15
分子量 596.534
别名 圣草次甙 ;Eriodictioside;eriodictyol 7-rutinoside;Eriocitrin, Eriodictioside, Eriodictyol 7-O-rutinoside;Eriodictyol 7-O-rutinoside;Eriodictyol glycoside
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 105 mg/mL(176.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Eriocitrin | 13463-28-0 | Apoptosis | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Eriocitrin 纯度/质量文件 | Eriocitrin 生物活性 | Eriocitrin 临床数据 | Eriocitrin 参考文献 | Eriocitrin 实验方案 | Eriocitrin 技术信息

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