Eriocitrin | 圣草次甙 | Eriodictioside | Antioxidant Agent

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圣草次苷 /Eriocitrin {[allProObj[0].p_purity_real_show]}

货号：A205759 同义名： 圣草次甙 / Eriodictioside;eriodictyol 7-rutinoside

Eriocitrin is a natural product isolated and purified from the fruits of Citrus sinensis (L.) Osbeck with antioxidative activity.

Eriocitrin 化学结构
CAS号：13463-28-0

Eriocitrin 3D分子结构
CAS号：13463-28-0

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Eriocitrin 纯度/质量文件产品仅供科研

货号：A205759 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Eriocitrin 生物活性

描述

Eriocitrin is a flavonoid isolated from lemon, which is a strong antioxidant agent. Eriocitrin could inhibit the proliferation of hepatocellular carcinoma cell lines by arresting cell cycle in S phase through up-regulation of p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating mitochondria-involved intrinsic signaling pathway^[3]. Eriocitrin attenuated oxidative injury and inflammatory response in rats with CI/R (cerebral ischemia reperfusion) via the Nrf2/HO-1/NQO1/NF-κB signaling pathway^[4]. Oral administration of eriocitrin (32 mg/kg/day for 28 days) improved dyslipidaemia and decreased lipid droplets in the liver. In HepG2 cells, eriocitrin also induced the corresponding orthologues, and reduced lipid accumulation under conditions of lipid loading^[5]. The 25 mg dose of eriocitrin had positive effects on oxidative stress, systemic inflammation and metabolism of lipids and glucose in general^[6].

Eriocitrin 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02627547	Healthy	Not Applicable	Completed	-	United Kingdom ... 展开 >> University of Glasgow School of Medicine Glasgow, United Kingdom 收起 <<
NCT03482401	Breast Cancer	Not Applicable	Active, not recruiting	June 1, 2019	Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 <<
NCT03215043	Pre Diabetes	Not Applicable	Recruiting	June 28, 2019	Brazil ... 展开 >> Sao Paulo State University "Julio de Mesquita Filho", Faculdade de Ciências Farmacêuticas Recruiting Araraquara, Sao Paulo, Brazil, 14800-903 Contact: Thais B Cesar, Ph.D. +55 16 3301-6927 tcesar@fcfar.unesp.br 收起 <<

Eriocitrin 参考文献

[1]Hiramitsu M, Shimada Y, et al. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014 Jan 15;4:3708.

[2]Minato K, Miyake Y, et al. Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver. Life Sci. 2003 Feb 21;72(14):1609-16.

[3]Wang Z, Zhang H, Zhou J, Zhang X, Chen L, Chen K, Huang Z. Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle. Cancer Chemother Pharmacol. 2016 Dec;78(6):1143-1150

[4]He J, Zhou D, Yan B. Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2/NQO-1/HO-1/NF-κB p65 proteins. Ann Transl Med. 2020 Jun;8(12):757

[5]Hiramitsu M, Shimada Y, Kuroyanagi J, Inoue T, Katagiri T, Zang L, Nishimura Y, Nishimura N, Tanaka T. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014 Jan 15;4:3708

[6]Ferreira PS, Manthey JA, Nery MS, Spolidorio LC, Cesar TB. Low doses of eriocitrin attenuate metabolic impairment of glucose and lipids in ongoing obesogenic diet in mice. J Nutr Sci. 2020 Dec 14;9:e59

Eriocitrin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.38mL

1.68mL

0.84mL

16.76mL

3.35mL

1.68mL

Eriocitrin 技术信息

CAS号	13463-28-0
分子式	C₂₇H₃₂O₁₅
分子量	596.534

别名	圣草次甙 ;Eriodictioside;eriodictyol 7-rutinoside;Eriocitrin, Eriodictioside, Eriodictyol 7-O-rutinoside;Eriodictyol 7-O-rutinoside;Eriodictyol glycoside
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(176.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

圣草次苷 /Eriocitrin {[allProObj[0].p_purity_real_show]}

Eriocitrin 纯度/质量文件产品仅供科研

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Eriocitrin 质控信息

Eriocitrin 生物活性

Eriocitrin 临床研究

Eriocitrin 参考文献

Eriocitrin 实验方案

Eriocitrin 技术信息

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圣草次苷 /Eriocitrin {[allProObj[0].p_purity_real_show]}

Eriocitrin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Eriocitrin 质控信息

Eriocitrin 生物活性

Eriocitrin 临床研究

Eriocitrin 参考文献

Eriocitrin 实验方案

Eriocitrin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Eriocitrin 纯度/质量文件产品仅供科研