产品说明书

Eriocitrin

Print
Chemical Structure| 13463-28-0 同义名 : 圣草次甙 ;Eriodictioside;eriodictyol 7-rutinoside;Eriocitrin, Eriodictioside, Eriodictyol 7-O-rutinoside;Eriodictyol 7-O-rutinoside;Eriodictyol glycoside
CAS号 : 13463-28-0
货号 : A205759
分子式 : C27H32O15
纯度 : 99%+
分子量 : 596.534
MDL号 : MFCD00017472
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(176.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Eriocitrin is a flavonoid isolated from lemon, which is a strong antioxidant agent. Eriocitrin could inhibit the proliferation of hepatocellular carcinoma cell lines by arresting cell cycle in S phase through up-regulation of p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating mitochondria-involved intrinsic signaling pathway[3]. Eriocitrin attenuated oxidative injury and inflammatory response in rats with CI/R (cerebral ischemia reperfusion) via the Nrf2/HO-1/NQO1/NF-κB signaling pathway[4]. Oral administration of eriocitrin (32 mg/kg/day for 28 days) improved dyslipidaemia and decreased lipid droplets in the liver. In HepG2 cells, eriocitrin also induced the corresponding orthologues, and reduced lipid accumulation under conditions of lipid loading[5]. The 25 mg dose of eriocitrin had positive effects on oxidative stress, systemic inflammation and metabolism of lipids and glucose in general[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02627547 Healthy Not Applicable Completed - United Kingdom ... 展开 >> University of Glasgow School of Medicine Glasgow, United Kingdom 收起 <<
NCT03482401 Breast Cancer Not Applicable Active, not recruiting June 1, 2019 Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 <<
NCT03215043 Pre Diabetes Not Applicable Recruiting June 28, 2019 Brazil ... 展开 >> Sao Paulo State University "Julio de Mesquita Filho", Faculdade de Ciências Farmacêuticas Recruiting Araraquara, Sao Paulo, Brazil, 14800-903 Contact: Thais B Cesar, Ph.D.    +55 16 3301-6927    tcesar@fcfar.unesp.br 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.38mL

1.68mL

0.84mL

16.76mL

3.35mL

1.68mL
参考文献

[1]Hiramitsu M, Shimada Y, et al. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014 Jan 15;4:3708.

[2]Minato K, Miyake Y, et al. Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver. Life Sci. 2003 Feb 21;72(14):1609-16.

[3]Wang Z, Zhang H, Zhou J, Zhang X, Chen L, Chen K, Huang Z. Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle. Cancer Chemother Pharmacol. 2016 Dec;78(6):1143-1150

[4]He J, Zhou D, Yan B. Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2/NQO-1/HO-1/NF-κB p65 proteins. Ann Transl Med. 2020 Jun;8(12):757

[5]Hiramitsu M, Shimada Y, Kuroyanagi J, Inoue T, Katagiri T, Zang L, Nishimura Y, Nishimura N, Tanaka T. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014 Jan 15;4:3708

[6]Ferreira PS, Manthey JA, Nery MS, Spolidorio LC, Cesar TB. Low doses of eriocitrin attenuate metabolic impairment of glucose and lipids in ongoing obesogenic diet in mice. J Nutr Sci. 2020 Dec 14;9:e59