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Edaravone-d5
Edaravone-d5
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货号：A1280771
同义名：
MCI-186-d5
Edaravone-d5 是 Edaravone 的氘代标记物，Edaravone 作为自由基清除剂，能够抑制与 MMP -9 相关的脑出血。
Edaravone-d5 化学结构
Edaravone-d5 3D分子结构
规格
价格
会员价
库存
数量
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Edaravone-d5 纯度/质量文件 产品仅供科研
货号：A1280771
标准纯度：
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产品说明书
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Edaravone-d5 质控信息
Marimastat
+++
MMP-7, IC50: 16 nM
MMP-14, IC50: 3 nM
98%
Ilomastat
++++
MMP-26, Ki: 0.36 nM
MMP-2, Ki: 0.1 nM
99%+
SB-3CT
+
MMP-2, Ki: 13.9 nM
MMP-9, Ki: 600 nM
99%+
Doxycycline
✔
98%
Batimastat
+++
MMP-7, IC50: 4 nM
MMP-1, IC50: 3 nM
99%+
Nobiletin
✔
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Edaravone-d5 生物活性
描述
Edaravone-d5 is a deuterium-labeled version of edaravone, enhancing its stability for experimental use. As a potent novel free radical scavenger, edaravone also plays a role in inhibiting MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator, further underscoring its potential in treating neurovascular disorders[1] [2] [3] [4]
Edaravone-d5 参考文献
[1] Yoshida, H., et al. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev, 2006. 12(1): p. 9-20.
[2] Okamura, K., et al. Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. Neurol Res, 2013.
[3] Garcia CA, et al. Edaravone reduces astrogliosis and apoptosis in young rats with kaolin-induced hydrocephalus. Childs Nerv Syst. 2016 Dec 17. [Epub ahead of print]
[4] Bai X, et al. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plast. 2016;2016:4034218. Epub 2016 Nov 10.
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Edaravone-d5 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
5.58mL
1.12mL
0.56mL
27.90mL
5.58mL
2.79mL
55.79mL
11.16mL
5.58mL
Edaravone-d5 技术信息
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