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Edaravone-d5

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Chemical Structure| 1228765-67-0 同义名 : MCI-186-d5
CAS号 : 1228765-67-0
货号 : A1280771
分子式 : C10H10N2O
纯度 : 98% +98%atom%D
分子量 : 179.23
MDL号 : MFCD34469834
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Edaravone-d5 is a deuterium-labeled version of edaravone, enhancing its stability for experimental use. As a potent novel free radical scavenger, edaravone also plays a role in inhibiting MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator, further underscoring its potential in treating neurovascular disorders[1].[2].[3].[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.58mL

1.12mL

0.56mL

27.90mL

5.58mL

2.79mL

55.79mL

11.16mL

5.58mL
参考文献

[1]Yoshida, H., et al. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev, 2006. 12(1): p. 9-20.

[2]Okamura, K., et al. Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. Neurol Res, 2013.

[3]Garcia CA, et al. Edaravone reduces astrogliosis and apoptosis in young rats with kaolin-induced hydrocephalus. Childs Nerv Syst. 2016 Dec 17. [Epub ahead of print]

[4]Bai X, et al. Protective Effect of Edaravone on Glutamate-Induced Neurotoxicity in Spiral Ganglion Neurons. Neural Plast. 2016;2016:4034218. Epub 2016 Nov 10.