产品说明书

E 64c

Print
Chemical Structure| 76684-89-4 同义名 : Loxistatin acid;NSC 694279;EP 475
CAS号 : 76684-89-4
货号 : A602643
分子式 : C15H26N2O5
纯度 : 95%
分子量 : 314.377
MDL号 : MFCD00132882
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(795.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Cysteine Protease
描述 E-64c is a derivative of a naturally occurring epoxide that inhibits cysteine proteases, particularly effective against papain. This inhibition is characterized by the hydrogen bonding and hydrophobic interactions between the ligands and the conserved residues within the catalytic binding site[1]. E-64c has been identified as a primary structure for the creation of irreversible inhibitors targeting cathepsin C[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.90mL

3.18mL

1.59mL

31.81mL

6.36mL

3.18mL
参考文献

[1]Khan MS, et al. Design, synthesis, evaluation and thermodynamics of 1-substituted pyridylimidazo[1,5-a]pyridine derivatives as cysteine protease inhibitors. PLoS One. 2013 Aug 5;8(8):e69982.

[2]Radzey H, et al. E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors. ChemMedChem. 2013 Aug;8(8):1314-21.

[3]Toda G, et al. Calcium-activated neutral protease inhibitor (E-64c) and reperfusion for experimental myocardial infarction. Jpn Heart J. 1989 May;30(3):375-86.