Ciprofibrate | Win35833 | Peroxisome Proliferator | AmBeed-信号通路专用抑制剂

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环丙贝特 /Ciprofibrate {[allProObj[0].p_purity_real_show]}

货号：A240639 同义名： Win35833;WIN 35,833

Ciprofibrate is an agonist of peroxisome proliferator-activated receptor PPAR⍺. It is used in dyslipidaemia.

Ciprofibrate 化学结构
CAS号：52214-84-3

Ciprofibrate 3D分子结构
CAS号：52214-84-3

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Ciprofibrate 纯度/质量文件产品仅供科研

货号：A240639 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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PPAR 亚型比较

产品名称	PPARα ↓ ↑	PPARβ/δ ↓ ↑	PPARγ ↓ ↑	PPARδ ↓ ↑	纯度
Fenofibric acid	✔				98%
GW6471	++ PPARα, IC50: 0.24 μM				99%+
GSK3787		++ PPARδ, pIC50: 6.6		++ PPARδ, pIC50: 6.6	99%+
FH535			✔		98%+
GW9662	+++ PPARα, IC50: 32 nM		+++ PPARγ, IC50: 3.3 nM		98%
T0070907			++++ PPARγ, IC50: 1 nM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ciprofibrate 生物活性

描述

Ciprofibrate is a potent peroxisome proliferator and increases the phosphorylation level of the PPARalpha. Ciprofibrate (500 μM; 4 hours) increases the PPARa phosphorylation level in rat Fao cells^[3]. In a LucLite assay, Ciprofibrate (10-100μM; 24 hours) induces PPARR activation by existing increased LUC activities in the rat liver H4IIEC3 cells transfected with PPRE-AB LUC reporter gene plasmid^[4]. A single dose of ciprofibrate (5 mg/kg by gastric intubation) significantly induces rat liver bilirubin conjugation as well as UGT1A1, UGT1A5 and PPARαexpression^[5]. The main effects of ciprofibrate on G cells are mediated from the antrum lumen, and the mechanism is dependent on PPAR-alpha^[6]. Ciprofibrate inhibited cigarette smoke extract-induced rat ASM cell contraction and proliferation in vitro. Ciprofibrate improved pulmonary function, inhibited airway hypercontraction, and ameliorated morphological small airway remodeling, including airway smooth muscle proliferation, in CS-exposed rats. Ciprofibrate also significantly reduced IL-1β, IL-12p70, IL-17A and IL-18 expression, which are related to airway remodeling, in the sera of CS-exposed rats^[7].

Ciprofibrate 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03031821	Prostate Cancer ... 展开 >> Metabolic Syndrome 收起 <<	Phase 3	Not yet recruiting	June 1, 2023	Canada, British Columbia ... 展开 >> BC Cancer Agency - Vancouver Cancer Centre Not yet recruiting Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Bernie Eigl, MD 604-877-6000 bernie.eigl@bccancer.bc.ca Principal Investigator: Bernie Eigl, MD 收起 <<
NCT01480687	Hypertension ... 展开 >>Hypertriglyceridemia 收起 <<	Phase 4	Unknown	December 2012	Brazil ... 展开 >> Hospital Universitario Pedro Ernesto Recruiting Rio de Janeiro, RJ, Rio de Janeiro, Brazil Contact: Marcela A Casanova, MSc 55-21-2868-8484 cela.abreu@gmail.com 收起 <<
NCT00350038	Hypertension ... 展开 >>Dyslipidemia 收起 <<	Phase 4	Completed	-	Hungary ... 展开 >> Sanofi-aventis Budapest, Hungary 收起 <<

Ciprofibrate 参考文献

[1]Clemencet MC, Muzio G, et al. Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate. Cancer Lett. 2005 May 26;222(2):217-26.

[2]Passilly P, Schohn H, Jannin B, Cherkaoui Malki M, Boscoboinik D, Dauca M, Latruffe N. Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol. 1999 Sep 15;58(6):1001-8.

[3]Passilly P, Schohn H, Jannin B, Cherkaoui Malki M, Boscoboinik D, Dauça M, Latruffe N. Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol. 1999 Sep 15;58(6):1001-8

[4]Rimando AM, Nagmani R, Feller DR, Yokoyama W. Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J Agric Food Chem. 2005 May 4;53(9):3403-7

[5]Heydel JM, Garnier P, Faure P, Artur Y. Ciprofibrate regulation of rat hepatic bilirubin glucuronidation and UDP-glucuronosyltransferases expression. Eur J Drug Metab Pharmacokinet. 2012 Dec;37(4):233-40

[6]Martinsen TC, Bakke I, Chen D, Sandvik AK, Zahlsen K, Aamo T, Waldum HL. Ciprofibrate stimulates the gastrin-producing cell by acting luminally on antral PPAR-alpha. Am J Physiol Gastrointest Liver Physiol. 2005 Dec;289(6):G1052-60

[7]Ke Q, Yang L, Cui Q, Diao W, Zhang Y, Xu M, He B. Ciprofibrate attenuates airway remodeling in cigarette smoke-exposed rats. Respir Physiol Neurobiol. 2020 Jan;271:103290

Ciprofibrate 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.46mL

0.69mL

0.35mL

17.29mL

3.46mL

1.73mL

34.58mL

6.92mL

3.46mL

Ciprofibrate 技术信息

CAS号	52214-84-3
分子式	C₁₃H₁₄Cl₂O₃
分子量	289.15

别名	Win35833;WIN 35,833;CCRIS 173;BRN 1984981;(±)-Ciprofibrate
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 105 mg/mL(363.13 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03031821	Prostate Cancer ... 展开 >> Metabolic Syndrome 收起 <<	Phase 3	Not yet recruiting	June 1, 2023	Canada, British Columbia ... 展开 >> BC Cancer Agency - Vancouver Cancer Centre Not yet recruiting Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Bernie Eigl, MD 604-877-6000 bernie.eigl@bccancer.bc.ca Principal Investigator: Bernie Eigl, MD 收起 <<
NCT01480687	Hypertension ... 展开 >>Hypertriglyceridemia 收起 <<	Phase 4	Unknown	December 2012	Brazil ... 展开 >> Hospital Universitario Pedro Ernesto Recruiting Rio de Janeiro, RJ, Rio de Janeiro, Brazil Contact: Marcela A Casanova, MSc 55-21-2868-8484 cela.abreu@gmail.com 收起 <<
NCT00350038	Hypertension ... 展开 >>Dyslipidemia 收起 <<	Phase 4	Completed	-	Hungary ... 展开 >> Sanofi-aventis Budapest, Hungary 收起 <<
NCT03662984	Myocardial Insulin Sensitivity... 展开 >> Impaired Glucose Metabolism Diastolic Dysfunction 收起 <<	Phase 3	Recruiting	August 30, 2020	Netherlands ... 展开 >> Nutrition and Movement Sciences Recruiting Maastricht, Limburg, Netherlands, 6200MD Contact: P Schrauwen, Prof 0031433882222 p.schrauwen@maastrichtuniversity.nl 收起 <<

环丙贝特 /Ciprofibrate {[allProObj[0].p_purity_real_show]}

Ciprofibrate 纯度/质量文件产品仅供科研

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Ciprofibrate 质控信息

Ciprofibrate 生物活性

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Ciprofibrate 参考文献

Ciprofibrate 实验方案

Ciprofibrate 技术信息

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环丙贝特 /Ciprofibrate {[allProObj[0].p_purity_real_show]}

Ciprofibrate 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Ciprofibrate 质控信息

Ciprofibrate 生物活性

Ciprofibrate 临床研究

Ciprofibrate 参考文献

Ciprofibrate 实验方案

Ciprofibrate 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

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