生物活性 | |||
---|---|---|---|
靶点 |
|
||
描述 | Bithionol is a potent sAC-specific inhibitor with IC50 value of 4μM[3]. Bithionol inhibited ATP production by working as a classical uncoupler in mitochondria isolated from mouse brain[4]. | ||
作用机制 | Bithionol binds to the sAC-specific, allosteric binding site for the physiological activator. It induces rearrangements of substrate binding residues and of Arg176, a trigger between the active site and allosteric site.[3] |
实验方案 | |||
---|---|---|---|
1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.81mL 0.56mL 0.28mL |
14.04mL 2.81mL 1.40mL |
28.09mL 5.62mL 2.81mL |
参考文献 |
---|